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ProteomicsHIV-1 Nef Reprograms Neuronal Lipid Rafts to Drive Neuroinflammation and Neurodegeneration in HIV-associated Neurocognitive Impairment
HIV-associated neurological disorders (HAND) remain a common co-morbidity of HIV infection. HIV protein Nef has been shown to increase the abundance of neuronal lipid rafts - cholesterol- and sphingolipid-rich membrane microdomains implicated in neurodegeneration and neuroinflammation. Here, we inve...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD065713 | Pride
Nef Exosomes. Neurons Hiv Hiv-associated neurological disorder Lipid rafts Neurodegeneration 
TranscriptomicsMicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease
MicroRNAs (miRNAs) have important roles in regulating a plethora of physiological and pathophysiogical processes including neurodegeneration. In both human immunodeficiency virus (HIV)-associated dementia in humans and its monkey model simian immunodeficiency virus encephalitis (SIVE), we find miR-2...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-55069 | biostudies-arrayexpress
UnknownSignatures of somatosensory cortical dysfunction in Alzheimer's disease and HIV-associated neurocognitive disorder.
Not available
S-EPMC9260304 | biostudies-literature
UnknownA Screening Strategy for HIV-Associated Neurocognitive Disorders That Accurately Identifies Patients Requiring Neurological Review.
Not available
S-EPMC4981762 | biostudies-literature
TranscriptomicsGene expression in the blood of SIV infected Rhesus macaques following in vivo PD-1 blockade
Hyperimmune activation is one of the strong predictors of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I interferon (IFN) signaling. Combination antiretroviral therapy suppresses hyperimmune activation only partially in HIV-infecte...
ORGANISM(S): Macaca mulatta 
2012-04-26 | E-GEOD-33933 | biostudies-arrayexpress
UnknownNeural dynamics of selective attention deficits in HIV-associated neurocognitive disorder.
Not available
S-EPMC6260195 | biostudies-literature
UnknownUp-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder.
Not available
S-EPMC3270964 | biostudies-literature
TranscriptomicsGene Expression Profiling of Tuberculous Meningitis coinfected with HIV
Tuberculosis co-infected with HIV may increase the risk of causing meningitis. Tuberculous meningitis co-infected with HIV associated with high mortality and severe neurological abnormalities in affected individuals. We have carried out TBM co-infected with HIV gene expression study using whole huma...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-29507 | biostudies-arrayexpress
UnknownCaspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder.
Not available
S-EPMC10834258 | biostudies-literature
UnknownGenetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.
Not available
S-EPMC3947559 | biostudies-literature
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