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As eosinophils are the densest and lowest abundant leukocytes, their isolation is cost-and labor intense. This sets restrictions on many aspects of eosinophilic research. Eosinophilic cell lines are available for use; however they are not characterized in much detail, yet. Cells of the HL-60 clone 1...
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD057747 | Pride
Gene expression profiles during the process of differentiation of HL-60 clone 15 cells into eosinophils [HL60cl15]
To investigate the changes in gene expression during the process of differentiation into eosinophils, microarray analysis was performed. HL-60 clone 15 cells were cultured with apicidin for 6 days. The cells were collected at four different time points and total RNA was prepared for use as a sample ...
ORGANISM(S): Homo sapiens 
2022-12-28 | GSE200826 | GEO
All-trans retinoic acid (ATRA)-based differentiation therapy has achieved success with the treatment of acute promyelocytic leukemia (APL), a unique subtype of acute myeloid leukemia (AML). However, other subtypes of AML display resistance to ATRA-based treatment. Here, we demonstrate that a novel n...
ORGANISM(S): Homo sapiens 
Analysis of molecular mechanism of neutrophil differentiation in HL-60 cells: effects of Ak2 hetero knockout, and difference from differentiation into eosinophil
Analysis of technical variance of ChIP-on-Chip studies by characterization of Myc-binding in HL60 cells. Keywords: Chip-on-chip Characterization of c-Myc binding in HL60 cells. Thirteen biologically independent replicates of growing HL60 cells were subjected to ChIP with an N-terminal c-Myc antibod...
ORGANISM(S): Homo sapiens 
Pluripotent stem cells can be isolated from early embryos or induced by cell fusion, somatic nuclear transfer, or expression of a selected set of transcription factors. Embryonic stem (ES) cells are characterized by an open chromatin configuration and high transcription levels achieved via autoregul...
ORGANISM(S): Mus musculus 
Pluripotent stem cells can be isolated from early embryos or induced by cell fusion, somatic nuclear transfer, or expression of a selected set of transcription factors. Embryonic stem (ES) cells are characterized by an open chromatin configuration and high transcription levels achieved via autoregul...
ORGANISM(S): Mus musculus 
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