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MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
ProteomicsA conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress
Mammalian TFEB and TFE3, as well as their ortholog in C. elegans HLH-30, play an important role in mediating cellular response to a variety of stress conditions, including nutrient deprivation, oxidative stress and pathogen infection. In this study we identify a novel mechanism of TFEB/HLH-30 regula...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022258 | Pride
Hlh-30 Tfeb Glutathionylation Tfe3 Lysosomes 
GenomicsHLH-30/TFEB is a master regulator of reproductive quiescence
HLH-30/TFEB is a master regulator of reproductive quiescence
PRJNA522776 | ENA
GenomicsHLH-30/TFEB-regulated autophagy mediates sexual dimorphism in immunity in Caenorhabditis elegans
HLH-30/TFEB-regulated autophagy mediates sexual dimorphism in immunity in Caenorhabditis elegans
PRJNA1028495 | ENA
GenomicsNeuronal HLH-30 regulates glp-1 longevity independent of neuronal MML-1/MXL-2
Neuronal HLH-30 regulates glp-1 longevity independent of neuronal MML-1/MXL-2
PRJNA981229 | ENA
TranscriptomicsMML-1/Mondo complexes regulate HLH-30/TFEB via TOR inhibition to promote longevity in response to signals from the reproductive system
Comprehensive transcriptome analysis of hlh-30, mml-1 and mxl-2 in N2 (wildtype) and glp-1 background.
ORGANISM(S): Caenorhabditis elegans 
2016-03-21 | E-MTAB-3686 | biostudies-arrayexpress
GenomicsNeuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans
Neuronal HLH-30/TFEB modulates muscle mitochondrial fragmentation to improve thermoresistance in C. elegans
PRJNA824428 | ENA
TranscriptomicsComparison of gene expression between wild type (N2) and hlh-30(tm1978) mutant worms
The hlh-30 gene encodes a C. elegans basic-helix-loop-helix (bHLH) transcription factor; We compared RNA from wild type worms and worms mutant for the hlh-30 gene to identify putative target genes of the HLH-30 transcription factor.
ORGANISM(S): Caenorhabditis elegans 
2009-07-24 | GSE15762 | GEO
GenomicsHLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans
HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans
PRJNA1381698 | ENA
GenomicsSimple Nutrients Bypass the Requirement for HLH-30 in Coupling Lysosomal Nutrient Sensing to Survival.
Simple Nutrients Bypass the Requirement for HLH-30 in Coupling Lysosomal Nutrient Sensing to Survival.
PRJNA520897 | ENA
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