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MetabolomicsSelective mTOR inhibition via FLCN drives TFE3-dependent VLDL-TG secretion and protects from MAFLD/MASH
Hepatic lipid homeostasis is controlled by multiple processes, including VLDL-TG secretion. We have previously shown that the FLCN/TFE3 branch of mTORC1 signaling controls hepatic fatty acid oxidation and de novo lipogenesis to protect mice from MAFLD. We now show that the FLCN/TFE3 pathway also con...
2026-09-08 | MTBLS15598 | MetaboLights
GenomicsTfe3-bound regions in naive pluripotent mouse embryonic stem (ES) cells
The bHLH transcription factor Tfe3 is a powerful regulator of pluripotency and we report a genome-wide analysis of Tfe3 occupancy in mouse ES cells. Nuclear localization of Tfe3 is inhibited by a protein complex containing the tumor-suppressor Folliculin (Flcn) and we also determine Tfe3 binding sit...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-39815 | biostudies-arrayexpress
TranscriptomicsEffects of SFPQ-TFE3 fusion in kidney tubuloids
The goal of this study was to analyse the effects of the SFPQ-TFE3 fusion by transforming kidney tubuloids with the construct. Samples without the construct (luciferase only) and overexpressing the partner only (TFE3) were also used as controls. Furthermore, transformed organoids were also transferr...
ORGANISM(S): Homo sapiens 
2025-02-28 | E-MTAB-13901 | biostudies-arrayexpress
TranscriptomicsCUT&RUN sequencing of human kidney tubuloid to study genome-wide binding site in tRCC patients
Translocation renal cell carcinoma (tRCC) is a rare, aggressive kidney cancer primarily occurring in children. They are genetically defined by translocations involving MiT/TFE gene family members, TFE3. We utilized human kidney organoids, or tubuloids, to engineer a tRCC model by expressing of one o...
ORGANISM(S): Homo sapiens 
2024-10-01 | E-MTAB-13900 | biostudies-arrayexpress
GenomicsTranscriptional regulation of the innate immune reponse by the MITF/TFE3 family
To understand the activation of the MITF/TFE transcription factors in effective defense against pathogens we examined the genome wide distribution of TFE3 in control and activated mouse macrophages. It was determined that TFEB and TFE3 collaborate with each other to promote efficient autophagy induc...
ORGANISM(S): Mus musculus 
2016-02-01 | E-GEOD-75822 | biostudies-arrayexpress
GenomicsHA-TFE3 bound regions in HK-2 HA-TFE3-inducible cells
HA-TFE3 bound regions in HK-2 HA-TFE3-inducible cells
PRJNA559085 | ENA
GenomicsHA-PRCC-TFE3 bound regions in HA-PRCC-TFE3 inducible HK-2 cells
HA-PRCC-TFE3 bound regions in HA-PRCC-TFE3 inducible HK-2 cells
PRJNA1183309 | ENA
GenomicsHA-PSF-TFE3 bound regions in HA-PSF-TFE3 inducible HK-2 cells
HA-PSF-TFE3 bound regions in HA-PSF-TFE3 inducible HK-2 cells
PRJNA1263461 | ENA
ProteomicsTFEB AND TFE3 DRIVE KIDNEY CYSTOGENESIS AND TUMORIGENESIS
Birt-Hogg-Dubè (BHD) syndrome is an inherited condition caused by loss-of-function mutations in the gene encoding the tumor-suppressor protein folliculin (FLCN) and frequently associated with kidney cysts and cancer. FLCN acts as a negative regulator of TFEB and TFE3 transcription factors, master co...
ORGANISM(S): Homo sapiens (Human) 
2023-04-04 | PXD035450 | Pride
Kidney Flcn Tfeb Tfe3 Rcc 
GenomicsPRCC-TFE3 Function and the Role of HIF1α and HIF2α in TFE3-Rearranged Renal Cell Carcinoma Development
PRCC-TFE3 Function and the Role of HIF1α and HIF2α in TFE3-Rearranged Renal Cell Carcinoma Development
PRJNA1195120 | ENA
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