Sort   by:  
 Page size 
Proteomics4-HNE modification of human recombinant Dicer
We used mass spectrometry analysis (nanoLC-MS/MS) to map 4-HNE-modified residues of human Dicer exposed in vitro to 4-HNE in a concentration-dependent maner
ORGANISM(S): Homo sapiens (Human) 
2023-11-17 | PXD034113 | Pride
Human dicer 4-hne Lc-ms/ms 
ProteomicsLC-MS/MS of HNE-apoE3 and HNE-apoE4
The overall goal of our study is to understand the effect of HNE modification on the structure and function of apolipoprotein E3 (apoE3) and apoE4, which play a critical role in brain cholesterol homeostasis. Immunoblots indicated HNE modification of recombinant apoE3 and apoE4 with a major band at ...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD038105 | Pride
Hne Apoe3 Apoe4 
TranscriptomicsEffect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
4-Hydroxynonenal (HNE), a cytotoxic and diffusible electrophile generated by the spontaneous decomposition of oxidized lipids, has a suspected role in neurodegenerative and inflammatory disease processes. In addition to promoting cell death, elevated levels of HNE lead to the engagement of cytoprote...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-12762 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HLE B-3 cells transfected with hGSTA4-4 expressing vector vs. controls
HLE B-3 cells were transfected with either empty vector or hGSTA4-4 expressing vector to lower intracellular 4-hydroxynonenal levels. hGSTA4-transfected sample has lower HNE levels than pTarget-transfected sample.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2298 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of human RKO cell line responses to 2-hydroxy-2-nonenal
Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2397 | biostudies-arrayexpress
ProteomicsThe Carnosine–HNE Michael Adduct as a Redox-Active Species Associated with Nrf2-Dependent Antioxidant and An-ti-Inflammatory Responses
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (H...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD075159 | Pride
Carnosine  4-hydroxy-2-nonenal (hne)  nrf2 activation  nf-κb  anti-inflammatory  anti-oxidant. 
ProteomicsLC-MS/MS data of specific proteins involved 4-HNE modification in bone formation
To elucidate the specific proteins involved in bone formation that are modified by 4-HNE, we performed LC-MS-based proteomics analysis. This approach identified several candidate proteins, including MAP kinase-activated protein kinase 3 (MAPK3), plastin-3 (PLS3), and integrin-linked protein kinase (...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-26 | MSV000096541 | MassIVE
ProteomicsPorcine Calpain-1 adduction (control, MDA, hexenal, and HNE modified calpain-1)
control samples raw files, MDA modified samples raw files, Hexenal modified samples raw files, HNE modified samples raw files
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) 
2022-11-16 | MSV000090726 | MassIVE
Genomics4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes
PRJNA631421 | ENA
ProteomicsHNE-modification identification of ApoAI
In this research, two 4-hydroxy-2-nonenal modified peptides with differential performance were identified in the plasma of patients with coronary artery disease, whether their antibodies were different in the plasma of patients with coronary artery disease and healthy people.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD041969 | Pride
Two 4-hydroxy-2-nonenal Apolipoprotein ai Coronary artery disease Autoantibody 
Sort   by:  
 Page size