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UnknownOptical Coherence Tomography Angiography (OCTA) Captures Early Micro-Vascular Remodeling in Non-Melanoma Skin Cancer During Superficial Radiotherapy: A Proof-of-Concept Study.
Not available
S-EPMC12607523 | biostudies-literature
ProteomicsBRD4 degradation via stabilization of a native interaction with DCAF16
Targeted protein degradation is a modality based on small molecules that induce proximity between a protein of interest (POI) and an E3 ubiquitin ligase, thus prompting POI ubiquitination and degradation. To expand the reach of TPD, current research is geared to unlock novel E3s. To that end, the tr...
ORGANISM(S): Homo sapiens (Human) 
2024-01-08 | PXD040570 | Pride
Brd4 degradation Kbm7 Small molecule induced proximity Chemical proteomics Gne-0011 Protac Orbitrap fusion lumos Lc-ms/ms 
ProteomicsCoronavirus PLPro interactome AP-MS data
Main proteases and papain-like proteases (PLpro) are essential coronaviral enzymes required for polypeptide processing during viral maturation. PLpro additionally cleave host cellular proteins to evade anti-viral immune responses. Here, we provide biochemical, structural and functional characterizat...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD018983 | Pride
Isgylation Ap-ms Sars-cov-2 Plpro 
ProteomicsTAK285 induced degradation – selectivity profiling in NALM-6 cells
The hit compound TAK285 was subjected to full proteome profiling by TMTpro 6-plex to assess its degradation selectivity in NALM-6 cells. TAK285 induced the degradation of the kinase BLK. The compound was further mechanistically dissected as reported with orthogonal assays such as FACS-based CRISPR/C...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD059599 | Pride
Kinase inhibitors Tmt 
UnknownSurveillance of multiple congenital anomalies; searching for new associations.
Not available
S-EPMC10999451 | biostudies-literature
ProteomicsSelectivity profiling of inhibitor treated human cells via full proteome profiling
Three selective hit compounds from an arrayed kinome abundance screen (98 kinases vs 1570 kinase inhibitors) were subjected to full proteome profiling by TMTpro 18-plex to assess their degradation selectivity in K562 cells. Src inhibitor 3 showed the most significant downregulation of the target kin...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD053130 | Pride
K562 Kinase inhibitors Monovalent degrader Tmt 
ProteomicsProbing kinase proximity interactome modulation upon drug treatment by miniTurboID proximity labelling
In a systematic effort to profile kinase inhibitors, which also act as degraders, we identified multiple hit compounds. These were subjected to detailed mechanism of action elucidation including analysis of the perturbed interactome and its effect on degradation. For our first example, LYN, Src inhi...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD062184 | Pride
Kinase inhibitors Tmt 
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
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