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MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
UnknownCrystal structure of poly[[di-aqua-tetra-μ2-cyanido-platinum(II)iron(II)] methanol 4/3-solvate]: a three-dimensional Hofmann clathrate analogue.
Not available
S-EPMC8819434 | biostudies-literature
UnknownA single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter.
Not available
S-EPMC7205462 | biostudies-literature
ProteomicsProteomic dissection of nanoparticle-containing vesicles reveals a major role for a macropinocytic-like uptake mechanism and multivesicular bodies during intracellular nanoparticle trafficking
Rational design of nanocarriers for drug delivery approaches requires an unbiased knowledge of uptake mechanisms and intracellular trafficking pathways. Here we dissected these processes using a quantitative proteomics approach. We isolated intracellular vesicles containing superparamagnetic iron ox...
ORGANISM(S): Homo sapiens (Human) 
2014-09-25 | PXD001175 | Pride
Human Hdmse Dia Intracellular trafficking Hela Synapt g2s Nanoparticles Endosomes Vesicles 
UnknownCombining electron transfer, spin crossover, and redox properties in metal-organic frameworks.
Not available
S-EPMC11339071 | biostudies-literature
UnknownProteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells.
Not available
S-EPMC8197937 | biostudies-literature
UnknownBiosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.
Not available
S-EPMC1479109 | biostudies-literature
UnknownDe novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition.
Not available
S-EPMC8116058 | biostudies-literature
UnknownNanocomposites comprised of homogeneously dispersed magnetic iron-oxide nanoparticles and poly(methyl methacrylate).
Not available
S-EPMC6009273 | biostudies-literature
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