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ProteomicsNeuronal proteome dynamics during homeostatic scaling.
Homeostatic scaling adjusts synaptic strength in response to persistent changes in neuronal network activity. This compensatory mechanism requires proteome remodeling accomplished via regulation of protein synthesis as well as degradation, but the global patterns of proteome remodeling and the under...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-03-31 | PXD016004 | Pride
Synaptic plasticity Proteome turnover Dynamic silac Proteome remodelling Homeostatic scaling 
ProteomicsNascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses.
Neuronal networks are subject to fluctuations in both the magnitude and frequency of inputs, requiring plasticity mechanisms to stabilize network activity. Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of neuronal connections up or down in response to large ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-12-22 | PXD004889 | Pride
Synaptic plasticity Q exactive plus Homeostatic scaling Lfq 
ProteomicsTime- and Polarity-dependent Proteomic Changes associated with Homeostatic Scaling at Central Synapses
In homeostatic scaling, the cellular mechanisms that detect the offset from the set-point, the duration of the offset and implement a cellular response are not well-understood. To understand the time-dependent dynamics,we manipulated activity for 2 hrs to induce the process of up or down-scaling and...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-02-16 | PXD008271 | Pride
Boncat Proteomics Homeostatic scaling 
ProteomicsHomer1a drives Homeostatic Scaling-down of Excitatory Synapses During Sleep
Homeostatic scaling is a global form of synaptic plasticity used by neurons to adjust overall synaptic weight and maintain neuronal firing rates while protecting information coding. While homeostatic scaling has been demonstrated in vitro, a clear physiological function of this plasticity type has n...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-13 | PXD004537 | Pride
Phosphoproteomics Sleep Homer1a 
GenomicsNPTX2, Homeostatic Scaling, and Schizophrenia
NPTX2, Homeostatic Scaling, and Schizophrenia
PRJNA633132 | ENA
TranscriptomicsHistone methylation by the Kleefstra Syndrome protein EHMT1 mediates homeostatic synaptic scaling.
Homeostatic plasticity, a form of synaptic plasticity, maintains the fine balance between overall excitation and inhibition in developing and mature neuronal networks. Although the synaptic mechanisms of homeostatic plasticity are well characterized, the associated transcriptional program remains po...
ORGANISM(S): Rattus norvegicus 
2016-06-30 | E-GEOD-68960 | biostudies-arrayexpress
GenomicsCompartment-specific regulation of gene expression orchestrates homeostatic synaptic scaling
Compartment-specific regulation of gene expression orchestrates homeostatic synaptic scaling
PRJNA650210 | ENA
Proteomicscompartmentalized protein expression in rat hippocampal neurons undergoing homeostatic plasticity
Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-09 | PXD020745 | Pride
Neurons Stimulation Homeostatic plasticity Hippocampus Rat Cellculture Ptx Dendrites 
GenomicsActivity-dependent history in hippocampal neurons dictates temporal dynamics of homeostatic synaptic scaling
Activity-dependent history in hippocampal neurons dictates temporal dynamics of homeostatic synaptic scaling
PRJNA750328 | ENA
ProteomicsPhosphorylation in synaptic plasticity
Homeostatic synaptic scaling is a compensatory mechanism that allows adjustment of the strength of synaptic connections up or down in response to changes in input to maintain global network stability. To characterize the molecular changes on the level of protein modification that contribute to synap...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-08-12 | PXD021834 | Pride
Phosphoproteomics Synaptic plasticity Bicuculline Neurons Tetrodotoxin Homeostatic scaling 
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