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ProteomicsIn vivo characterization of the bacterial intramembrane-cleaving protease RseP using the heme binding tag-based assay iCliPSpy
Purified, putative unprocessed and processed MBPmut-TNFa fusion proteins were analyzed by LC-MS. The average molecular weights of the eluted MBPmut-TNFa fusion proteins obtained by deconvolution of the ESI-MS spectra are given. For MBPmut-TNFa preparations from “Empty vector control” and “RseP-Myc H...
ORGANISM(S): Escherichia coli 
2023-03-20 | PXD038785 | Pride
Tnf Fusion protein Intact mass analysis Lc-msms Intermembrane protease 
ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Mus Musculus (ncbitaxon:10090) 
MSV000086102 | MassIVE
ProteomicsAnalysis of Amyloid Plaque Composition in two mouse models of Alzheimer’s disease
MALDI mass spectrometry imaging (MSI) enables label-free, spatially resolved analysis of a wide range of analytes in tissue sections. Quantitative analysis of MSI datasets is typically performed on single pixels or manually assigned regions of interest (ROI). However, many sparse, small objects such...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-15 | PXD020824 | Pride
Alzheimer Maldi Ms imaging Amyloid plaques Linear positive mode Abeta 
ProteomicsSpatial distribution of endogenous tissue protease activity in gastric carcinoma mapped by MALDI mass spectrometry imaging
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-25 | PXD010369 | Pride
Gastric mouse carcinoma Lc-ms Sp3 Proteases Maldi 
ProteomicsTissue protease activity with MALDI MSI
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Bos taurus (Bovine) Mus musculus (Mouse) 
2020-08-06 | PXD011104 | Pride
Protease activity Maldi-msi 
ProteomicsIntegrative single-plaque analysis reveals signature Aβ and lipid profiles in the Alzheimer’s brain
Utilizing multimodal mass spectrometry imaging (MSI) combined with machine learning techniques, this study investigates the molecular heterogeneity of amyloid-β (Aβ) plaques and associated lipid profiles in post-mortem brain samples from Alzheimer’s disease (AD) and amyloid-positive cognitively unaf...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD049325 | Pride
Alzheimer’s disease Amyloid-β Maldi ms imaging Gangliosides Machine learning 
TranscriptomicsMALDI imaging MS reveals candidate lipid markers of polycystic kidney disease
Autosomal recessive polycystic kidney disease is a severe, monogenetically inherited kidney and liver disease and PCK rats carrying the orthologous mutant gene serve as a model of human disease. We combined selective MALDI imaging of sulfated kidney lipids and Fisher discriminant analysis of imaging...
ORGANISM(S): Rattus norvegicus 
2013-12-01 | E-GEOD-48357 | biostudies-arrayexpress
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