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UnknownElectrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection.
Not available
S-EPMC6541367 | biostudies-literature
ProteomicsComprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes
Monocytes are a critical component of the cellular innate immune system, and can be subdivided into classical, intermediate and non-classical subsets on the basis of surface CD14 and CD16 expression. Classical monocytes play the canonical role of phagocytosis, and account for the majority of circula...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD013832 | Pride
Classical monocyte Monocyte Blood cell Cell surface Quantitative proteomics Tandem mass tag Plasma membrane 
ProteomicsHuman cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate and adaptive immunity. We have employed two novel, orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins downregulated by viral factors e...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2022-02-22 | PXD026785 | Pride
Human cytomegalovirus  restriction factor  innate immunity  immune evasion  host-pathogen interaction  schlafen 
UnknownSurface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma.
Not available
S-EPMC10905525 | biostudies-literature
ProteomicsA comprehensive evaluation of the Ewing sarcoma surface and global proteomes reveals actionable immunotherapeutic targets.
Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory d...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD043375 | Pride
Ewing sarcoma Surfaceome 
ProteomicsThe translatome of quiescent Plasmodium falciparum gametocytes reveals parasite pyridoxal 5’-phosphate (PLP) biosynthesis is essential for efficient mosquito stage development
The ability of Plasmodium falciparum gametocytes to remain quiescent within the vertebrate host but poised for rapid onward development in the mosquito is an adaptation essential to maximise the onward spread of malaria. In this dormant state, mature infectious stage V gametocytes are largely unaffe...
ORGANISM(S): Plasmodium falciparum 
2026-03-25 | PXD075878 | Pride
Malaria Plasmodium falciparum Translatome 
ProteomicsComparative cell surface proteomic analysis of the primary human T cell and monocyte responses to type I interferon
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry for viruses. Nonetheless, the effect of IFN on PM ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD022834 | Pride
T cell Leukocytes Cell surface Antiviral restriction Monocyte Quantitative proteomics Interferon type i (ifn) Plasma membrane 
UnknownAmerican Society of Hematology 2023 guidelines for management of venous thromboembolism: thrombophilia testing.
Not available
S-EPMC10709681 | biostudies-literature
UnknownEffectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study.
Not available
S-EPMC8930006 | biostudies-literature
Genomics7635cfb5-4bb5-44fa-9d28-3760b584ba69 - samples
This dataset contains CTCF ChIP-sequencing data from seven samples (six tumor samples and one tumor derived cell line). Following library amplification, DNA fragments were sequenced using Illumina HiSeq 2000 paired-end sequencing resulting in 14 FASTQ files.
EGAD00001008806 | EGA
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