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ProteomicsDifferential impact of LPS and LTA stimulation on differentiated bone marrow and Yolk sac Hoxb8 macrophages
The impact of LPS and LTA stimulation on differentiated bone marrow and Yolk sac Hoxb8 macrophages in comparison to untreated control cells was studied by global protein profiling using a bottom-up approach.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-04 | PXD026922 | Pride
Lps Lc-ms/ms Hoxb8 Bone marrow Yolk sac Lta Macrophages 
TranscriptomicsGeneration of hematopoietic progenitor cell lines with myeloid and lymphoid potential using a conditional form of Hoxb8
Investigation of immune cell differentiation and function is limited by shortcomings of suitable and scalable experimental systems. Although forced expression of certain Hox genes allows immortalization of hematopoietic progenitor cells, their differentiation potential is limited to select myeloid l...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-45759 | biostudies-arrayexpress
ProteomicsFull proteome analysis of Hoxb8 immortalized murine myeloid progenitors knockout for CCDC134 and differentiated into macrophages
We recently identified CCDC134 as a novel regulator of TLR responses. To gain a comprehensive understanding of the effects of CCDC134 loss, we conducted total proteome analysis on control sgRen and sgCCDC134 Hoxb8 immortalized murine myeloid progenitors that were differentiated into macrophages. Int...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-14 | PXD053042 | Pride
Ccdc134 Full proteome Hoxb8 macrophages 
ProteomicsProteomic analysis of HoxB8-derived macrophages in which the Slc31a1 or Atp7a genes were inactivated using CRISPR/Cas9
This project is part of a study aimed at elucidating how Mycobacterium tuberculosis responds to physiologically relevant copper levels during macrophage infection. Here, we conducted a proteomic analysis of macrophages derived from immortalized HoxB8 hematopoietic precursors, in which the Slc31a1 (e...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-25 | PXD076718 | Pride
Copper receptors Atp7a Slc31a1 Macrophages 
UnknownMicroglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres Syndrome neuropathology.
Not available
S-EPMC11430044 | biostudies-literature
UnknownMicroglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutieres syndrome neuropathology.
Not available
S-EPMC12844908 | biostudies-literature
GenomicsMicroglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
PRJNA1390662 | ENA
GenomicsRNA sequencing of Hoxb8 yolk sac- and bone marrow-derived
RNA sequencing of Hoxb8 yolk sac- and bone marrow-derived
PRJNA736088 | ENA
TranscriptomicsMicroglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi-Goutières Syndrome neuropathology
Microglia, the brain’s resident macrophages, can be reconstituted by surrogate cells - a process termed “microglia replacement.” To expand the microglia replacement toolkit, we here introduce estrogen-regulated (ER) homeobox B8 (Hoxb8) conditionally immortalized macrophages, a cell model for generat...
ORGANISM(S): Mus musculus 
2025-12-18 | GSE314288 | GEO
UnknownDefining the Hoxb8 cell lineage during murine definitive hematopoiesis.
Not available
S-EPMC9124572 | biostudies-literature
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