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ProteomicsDiscovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription
Aberrant activation of androgen receptor (AR)-dependent transcriptional programs is a hallmark of human prostate cancers. At the molecular level, ligand-mediated AR activation is coordinated through spatial and temporal protein-protein interactions (PPIs) involving AR-interacting proteins, which we ...
ORGANISM(S): Homo sapiens (Human) 
2016-07-20 | PXD002861 | Pride
Androgen Transcription Intracellular trafficking Prostate cancer Protein trafficking Mass spectrometry-based proteomics Androgen receptor Golgi membrane 
ProteomicsMolecular signatures of membrane protein complexes underlying muscular dystrophy
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating ...
ORGANISM(S): Mus musculus (Mouse) 
2016-04-22 | PXD004020 | Pride
Mouse Glycoproteomics Sucrose fractionation Directed ms Skeletal muscle 
ProteomicsMolecular signatures of membrane protein complexes underlying muscular dystrophy
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-12 | PXD002846 | Pride
Mouse Directed ms (dms) Skeletal muscle Membrane protein complexes 
ProteomicsAndrogen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells
Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic re...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD002913 | Pride
Androgen Human prostate cancer cells Lectin affinity purification 
ProteomicsAndrogen Receptor Activity is Regulated Through the Mobilization of Cell Surface Receptor Networks
The aberrant expression of androgen receptor (AR)-dependent transcriptional programs is a defining pathology of the development and progression of prostate cancers. Transcriptional cofactors that bind AR are critical determinants of prostate tumorigenesis. To gain a deeper understanding of the prote...
ORGANISM(S): Homo sapiens (Human) 
2015-09-03 | PXD002596 | Pride
Lncap Prostate cancer Androgen receptor 
TranscriptomicsExpression data from CL1-0 and CL1-5 lung cancer cell line.
A lung cancer cell model of invasive transformation was developed to select progressively invasive cell populations from a parental cell line of human lung adenocarcinoma, CL1. Five progressive sub-clones namely, CL1-1, CL1-2, CL1-3 CL1-4, and CL1-5 were selected using transwell and displayed increa...
ORGANISM(S): Homo sapiens 
2012-12-11 | E-GEOD-42407 | biostudies-arrayexpress
TranscriptomicsExpression data from AK4 overexpression in CL1-0 lung cancer cell line and AK4 knockdown in CL1-5 lung cancer cell line
We demonstrate that AK4 down-regulation shRNAs significantly reduced cell migration and invasion in highly invasive lung cancer cell lines in vitro, as well as in lung metastases in vivo We used microarrays to analyze the AK4 regulated gene expression underlying invasion-metastasis cascade. CL1-0 lu...
ORGANISM(S): Homo sapiens 
2012-12-03 | E-GEOD-37903 | biostudies-arrayexpress
TranscriptomicsExpression data from FDFT1 overexpression lung cancer cell lines.
FDFT1 catalyzes the first reaction in the mevalonate/isoprenoid pathway, we demonstrated that FDFT1 down-regulation by two shRNAs significantly reduced cell migration and invasion in highly invasive lung cancer cell lines in vitro, as well as in lung metastases in vivo. We used microarrays to detail...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-37868 | biostudies-arrayexpress
ProteomicsThe interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond: LC-MS/MS Dataset
LC-MS/MS analysis of a gel slice containing a disulfide-cross-linked peptide chains between thioredoxin-1 and the NACHT-LRR domains of NLRP1
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD047547 | Pride
Disulfide Lc-ms Nlrp1 Trx1 
TranscriptomicsExpression data from G9a overexpression and knockdown lung cancer cell lines
G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regionsand is essential for murine embryogenesis . We demonstrate that G9a is endowed with methyltransferase activity to concomitantly repress the downstream effector Ep-CAM, thereby promoting the invasion step of the invasi...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-22810 | biostudies-arrayexpress
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