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ProteomicsQuantitative phosphoproteomic analysis of acquired drug resistance to pazopanib and dasatinib
Acquired drug resistance and tumour relapse impacts the majority of patients being treated with tyrosine kinase inhibitors (TKIs) and remains a key challenge in modern anti-cancer therapy. The lack of clinically effective therapeutic strategies to overcome drug resistance represents a significant un...
ORGANISM(S): Homo sapiens (Human) 
2017-08-30 | PXD005536 | Pride
Resistance Dasatinib Pazopanib A204 Phosphoproteomics 
UnknownProtamine is an antagonist of apelin receptor, and its activity is reversed by heparin.
Not available
S-EPMC6191096 | biostudies-literature
ProteomicsIdentification of regulators of polyploidization presents therapeutic targetsfor treatment of AMKL
Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Go...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-01-27 | MSV000078536 | MassIVE
UnknownTargeting strategies for bone diseases: signaling pathways and clinical studies.
Not available
S-EPMC10192458 | biostudies-literature
ProteomicsSWATH mass spectrometry as a tool for quantitative profiling of the matrisome
Proteomic analysis of extracellular matrix (ECM) and ECM-associated proteins, collectively known as the matrisome, is a challenging task due to its inherent complexity and insolubility. Here we present sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH MS)...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-19 | PXD008651 | Pride
Proteomics Mass spectrometry Dia ms Extracellular matrix Matrisome Swath ms 
UnknownPrevalence and Predictors of Sperm Banking in Adolescents Newly Diagnosed With Cancer: Examination of Adolescent, Parent, and Provider Factors Influencing Fertility Preservation Outcomes.
Not available
S-EPMC5707206 | biostudies-literature
ProteomicsLC-MSMS of cell secretome for MAP1LC3B interactors
Description Growing evidence implicates autophagy in cell secretion. Identifying the repertoire of proteins involved with autophagy dependent secretions is key for understanding the underlying mechanism. We initially use a proximity-dependent biotinylation proteomics strategy to label protein that e...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD015479 | Pride
Autophagy Proximity-tagged ms Exosome Bira Secretome 
ProteomicsLC-MSMS of cell secretome for MAP1LC3B interactors
Growing evidence implicates autophagy in cell secretion. Identifying the repertoire of proteins involved with autophagy dependent secretions is key for understanding the underlying mechanism. We use a proximity-dependent biotinylation proteomics strategy to label protein that engage the autophagy ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD006541 | Pride
Lc-msms Autophagy Silac Map1lc3b Human Bioid Secretome 
ProteomicsNardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of apoptotic pathways. Here, we find that development of anoikis resistance and metastasis of KrasG12D-driven PDAC in mice is accelerated by deleting Plk3, ex...
ORGANISM(S): Homo sapiens (Human) 
2023-12-23 | PXD042993 | Pride
Plk3 Nardilysin (nrdc) metalloendopeptidase cleavage C-fos Anoikis Pancreatic ductal adenocarcinoma (pdac) Post-translational mechanism (ptm) Genetically engineered mouse models (gemms) Plk1 Kinase activation Metastasis 
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
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