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ProteomicsAging in pancreatic ductal adenocarcinoma
Aging is a critical yet understudied determinant in pancreatic ductal adenocarcinoma (PDAC). Despite a strong epidemiological association with age, conventional PDAC preclinical models fail to capture the histopathological and stromal complexities that emerge in older organisms. Using an age-relevan...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD068597 | Pride
Pancreatic ductal adenocarcinoma Cancer-associated fibroblasts Aging Immunosuppression Metastasis 
ProteomicsThe human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa
To combat infections, the mammalian host limits availability of essential transition metals such as iron (Fe), zinc (Zn), and manganese (Mn) in a strategy termed “nutritional immunity”. The innate immune protein calprotectin (CP) contributes to nutritional immunity by sequestering these metals to ex...
ORGANISM(S): Pseudomonas aeruginosa PA14 
2021-07-29 | PXD027638 | Pride
Innate immune Calprotectin Multi-metal starvation Pseudomonas aeruginosa 
ProteomicsNew molecular insights into atrial fibrillation due to obscurin Ig58/59 deletion
Obscurins are giant, modular, cytoskeletal proteins that regulate striated muscle structure and function. Immunoglobulin domains 58/59 (Ig58/59) of obscurin interact with diverse proteins including titin variants and phospholamban. Mutations within Ig58/59 that alter these binding interactions have ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-11 | PXD028904 | Pride
Arrhythmia Z-disk Ca2+ cycling Obscurin Atrial fibrillation 
ProteomicsDifferential patterns of protein expression in monolayer or spheroid melanoma cell models of acquired resistance to BRAF and MEK1/2 inhibitors
Mitogen activated protein kinase (MAPK) inhibitors are important therapies for treating many cancers. However, the development of acquired resistance to most protein kinase inhibitors limit their ability to provide durable responses. Approximately 50% of malignant melanomas contain activating mutati...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026952 | Pride
Monolayer Braf Drug resistance Protein kinases Kinase targeted therapy Selumetinib Spheroids Melanoma Vemurafenib Extracellular-signal regulated kinases 
ProteomicsRole of cellular retinol-binding protein, type 1 and retinoid homeostasis in the adult mouse heart: a multi-omic approach
The main active metabolite of Vitamin A, all-trans retinoic acid (RA), is responsible for proper cellular function and tissue organization. The role of RA has been extensively studied in development, but there is limited research on its role in the adult heart. Cellular retinol-binding protein, type...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD029349 | Pride
Heart Retinoid metabolism Mice Retinoic acid Cellular retinol binding protein type 1 
ProteomicsNoncoding dsRNA induces Retinoic Acid synthesis to stimulate regeneration
We uncover a novel mechanism whereby developmental pathways are reactivated in adults to promote regeneration.
ORGANISM(S): Homo sapiens (Human) 
2019-05-23 | PXD013854 | Pride
Regeneration Retinoic acid Noncoding dsrna 
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