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MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
TranscriptomicsTranscription profiling of stroke-susceptible and asymptomatic human carotid plaques
A microarray analysis of advanced human atherosclerotic carotid artery plaques (equal or over 70% stenosis, NASCET criteria) from radiologically confirmed ipsilateral stroke patients (stroke-susceptible plaques, n=12) compared with carotid plaques collected from clinically asymptomatic patients with...
ORGANISM(S): Homo sapiens 
2011-12-30 | E-MEXP-2257 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient
We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asympto...
ORGANISM(S): Homo sapiens 
2006-02-10 | E-MEXP-268 | biostudies-arrayexpress
MetabolomicsHuaban Tongmai Decoction ameliorates carotid artery atherosclerosis by inhibiting ferroptosis via the p53-Parkin mitophagy axis

Background: Carotid artery atherosclerosis (CAS), has exhibited an increasing incidence in recent years. Although Huaban Tongmai decoction (HBTMD) shows considerable therapeutic potential against CAS, the specific molecular mechanisms of its action remain incompletely defined.

Purpose: This...

2026-02-15 | MTBLS13908 | MetaboLights
MetabolomicsIntegrated Proteomics and Metabolomics Analyses Revealed Potential Phospholipid-Related Biomarkers in Rabbit Atherosclerotic Plaques

BACKGROUND AND AIMS: Atherosclerosis, characterized by dysfunction of lipid metabolism and chronic inflammation, is considered as a metabolic disorder as well as a major contributor to cardiovascular diseases. However, metabolic signatures of atherosclerosis have not been well ex...

2024-09-26 | MTBLS9737 | MetaboLights
TranscriptomicsChanges in miR expression profile carotid plaques induced by acutely induced flow disturbances in apoe-/- mice on a high fat diet.
Atherosclerosis is causally related to disturbed flow through low and oscillatory shear stress. In order to study the miR expression profile in atherosclerotic plaques induced by disturbed flow, partial ligation of the carotid artery was performed. This procedure results acutely in severly reduced b...
ORGANISM(S): Mus musculus 
2012-12-26 | E-GEOD-26555 | biostudies-arrayexpress
ProteomicsRegion-specific lipid markers of plaque outcome revealed by mass spectrometry imaging of human carotid atherosclerotic plaques
The goal of the project is the detection of region-specific lipid features that discriminate between symptomatic and asymptomatic human carotid atherosclerotic plaques by MALDI MSI.
ORGANISM(S): Homo sapiens (Human) 
2025-01-04 | PXD039822 | Pride
Atherosclerosis Maldi msi Lipids Plaque outcome 
ProteomicsMolecular Landscape of Atherosclerotic Plaque Progression: Insights from Proteomics
This dataset comprises proteomic profiles of 87 human carotid atherosclerotic plaques from patients undergoing carotid endarterectomy (CEA). The study employed an integrated approach using Data Independent Acquisition (DIA) proteomics. A total of 87 human carotid plaques were analyzed to identify an...
ORGANISM(S): Homo Sapiens 
2025-03-26 | PXD062283 |
ProteomicsProteomic analysis of distinct regions of human carotid atherosclerotic plaques
Protein profiles were determined from different distinct regions of human atherosclerotic plaques, including: internal control, fatty streak, plaque shoulder, plaque centre, and fibrous cap. Protein extracts from all 5 regions, from 3 men and 3 women, were separated by two-dimensional gel electropho...
ORGANISM(S): Homo sapiens (Human) 
2016-05-24 | PXD003930 | Pride
Human Carotid artery Ms/ms Peptide mass fingerprinting Atherosclerosis 
ProteomicsProteomic Analysis of Carotid Artery Plaques With and Without Vulnerable Features on Magnetic Resonance Angiography with Vessel Wall Imaging: A Pilot Study
Single-center, cohort study of plaques identified with and without vulnerable features on magnetic resonance angiography with vessel wall imaging. Proteomic analysis of these plaques demonstrates different protein composition. These proteins may be used for early detection and intervention or as pha...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD052120 | Pride
Lc-msms Human carotid plaques Lcm/ffpe 
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