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GenomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (Chip-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56567 | biostudies-arrayexpress
TranscriptomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (RNA-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56568 | biostudies-arrayexpress
TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
Background: The human genome consists of considerable portions derived from retroviruses inherited for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERVs exist. The HERV-K(HML-2) group includes evolutionarily young proviru...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD013296 | Pride
Proteolysis Retrovirus 
TranscriptomicsRNA-Seq after knockdown of the endogeneous retrovirus HERVH in human embryonic stem cells
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements whose members are expressed preferentially in human pluripotent stem cells. Here, we report that the long-terminal repeat regions of HERVH function as enhancers which are regulated by OCT4. Strikingly, we found that ...
ORGANISM(S): Homo sapiens 
2014-03-30 | E-MTAB-2072 | biostudies-arrayexpress
ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
The human genome consists of considerable portions derived from retroviruses typically inherited already for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERV sequences exist. The HERV-K(HML-2) group includes evolutionaril...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD010159 | Pride
Protease N-terminomics 
ProteomicsEndogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology
The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. The human genome is replete with sequences derived from foreign elements including endogenous retrovirus-like proteins of unknown function. Here we show that UB...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD061852 | Pride
Stress granules Retrotransposon-derived proteins Ubiquilins 
GenomicsARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription
ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription
PRJNA748378 | ENA
TranscriptomicsRepeat elements study in pluripotent stem cells [RNA-seq]
We surveyed RNA-Seq data to identify those TEs that are transcriptionally active uniquely in human pluripotent cells. We identified one endogenous retrovirus (HERV-H) family, uniquely found in primates as being unusually abundant in the transcriptome. Poly(A)+ RNA extraction and further sequencing l...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-44646 | biostudies-arrayexpress
UnknownHuman endogenous retrovirus-K mRNA expression and genomic alignment data in hepatoblastoma.
Not available
S-EPMC7330144 | biostudies-literature
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