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ProteomicsComprehensive phosphoproteomics characterization identify drug targets of liver cancer
Recurrence and metastasis remain the major obstacles to prognosis of hepatocellular carcinoma (HCC), but the relationship between phosphoproteomics and drug targets need to be studied more systematically. In this study, we performed the phosphoproteomics data collected from 18 paired HCC patients to...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD047213 | Pride
Phosphoproteomics  human  hcc 
Proteomics(Phospho)-proteomic characterization of longitudinal biopsies from HCC patients treated with sorafenib
Tumor response rates to targeted therapy are generally low. This poses an urgent medical need to identify molecular mechanisms that determine responsiveness, to inform drug development and therapy. Here, we performed a proteomics and phospho-proteomics (p)proteomics analysis on longitudinal tumor bi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD028593 | Pride
Human Super-silac Sorafenib (phospho)-proteomics ((p)proteomics) Hepatocellular carcinoma (hcc) Biopsies 
ProteomicsMicrocystin-LR activates serine/threonine kinases and alters the phosphoproteome in human HepaRG cells
Microcystin-LR (MCLR) exposure has been associated with development of hepatocellular carcinoma (HCC). Many of the carcinogenic mechanisms for MCLR have been attributed to the induction of cell survival and proliferation through altered protein phosphorylation pathways by inhibition of protein phosp...
ORGANISM(S): Homo sapiens (Human) 
2025-02-05 | PXD054405 | Pride
Protein phosphatase Mitogen-activated protein kinase Microcystin-lr Protein phosphorylation Phosphoproteomics Heparg cells 
ProteomicsPhosphoproteomics attributes aberrant signaling events to a druggable kinome in hepatocellular carcinom
To connect aberrant phospho-signaling events to therapeutic vulnerabilities in hepatocellular carcinoma (HCC), we performed a mass-spectrometry-based phosphoproteomic quantification of human HCC tumors, adjacent tissues and cell lines. We developed an integrated pipeline as the inference of druggabl...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD023840 |
ProteomicsFeasibility of phosphoproteomics on left-over sample after RNA extraction (RNA-Bee)
In daily practice biomolecules are usually extracted with their own specific protocols for downstream omics analysis. However, when sample material is limited, an all-in-one strategy is preferable. DNA, RNA and proteins can be isolated with phenol guanidine thiocyanate based extraction, yet lysis wi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-04-22 | PXD023665 | Pride
Phenol guanidine thiocyanate Tissue Lysis Rnab Phosphoproteomics Cell line 
Proteomicshuman liver cancer Phosphoproteomics
Effect of Aminopeptidase N on Hepatocellular Carcinoma
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD016468 | Pride
Human hcc phosphoproteomics 
UnknownIntegrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A (PRKACA) and Its Oncogenic Mutant DNAJB1-PRKACA.
Not available
S-EPMC10153428 | biostudies-literature
ProteomicsHBV remodels PP2A complexes to rewire kinase signaling in hepatocellular carcinoma
Hepatitis B virus (HBV) infection promotes liver cancer initiation by inducing inflammation and cellular stress, but its impact in established tumors is not well understood. We used affinity purification mass spectrometry to comprehensively map a network of 145 physical interactions between HBV and ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-23 | PXD055366 | Pride
Hepatitis b Pp2a Signaling Hepatocellular carcinoma 
ProteomicsPlectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis – in vitro phosphoproteomics
The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plec...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD060083 | Pride
Hepatocellular carcinoma  plectin  plecstatin-1 Target Metastasis 
UnknownIdentification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells.
Not available
S-EPMC2770568 | biostudies-literature
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