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TranscriptomicsRNA-seq analysis of astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape
The host response of the primary intestinal epithelium to human astrovirus (HAstV infection has not been elucidated to date. In order to characterize the global effects of AstV infection on human intestinal tissue, we performed transcriptional profiling of VA1-infected human intestinal enteroids (HI...
ORGANISM(S): Homo sapiens 
2019-10-31 | E-MTAB-8527 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of Adult and Fetal Enteroids (Control or Treated with DBZ)
Bulk RNA sequencing data of both adult and fetal enteroid lines cultured for 1 or 3 days. Conditions include enteroids grown in control basal media and basal media with the notch inhibitor DBZ added.
ORGANISM(S): Homo sapiens 
2022-04-08 | E-MTAB-11619 | biostudies-arrayexpress
GenomicsHuman norovirus efficiently replicates in differentiated 3D-human intestinal enteroids
Human norovirus efficiently replicates in differentiated 3D-human intestinal enteroids
PRJNA843063 | ENA
TranscriptomicsSingle cell sequencing data of developing human intestine tissue and human and chimpanzee intestine organoids
To study the species difference in developing intestine between human and chimpanzees, we performed scMultiome profiling on developing human intestine tissues and matched intestinal epithelial only organoids (also known as enteroids), and performed scRNA-seq and scATAC-seq measurements on human and ...
ORGANISM(S): Pan troglodytes 
2025-08-08 | E-MTAB-15112 | biostudies-arrayexpress
GenomicsTranscriptional Response to Pool Human Milk Exosomes in Infant Ileal Intestinal Enteroids
Transcriptional Response to Pool Human Milk Exosomes in Infant Ileal Intestinal Enteroids
PRJNA1419770 | ENA
ProteomicsProteomic and functional profiling of suspended jejunal enteroids reveals physiological and pharmacokinetic fidelity to native intestine
Intestinal enteroids are “mini-guts” that recapitulate essential features of the intestinal epithelium in vitro. We developed and characterized native basal-out (BO) and morphogenically everted apical-out (AO) jejunal enteroids cultured in suspension. Using quantitative proteomics, we show that thes...
ORGANISM(S): Homo sapiens (Human) 
2026-08-21 | PXD067571 | Pride
Pbpk modeling Proteomics Drug metabolism Enteroids Live-cell microscopy Drug transport Human small intestine 
ProteomicsMaturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack
Enteroid-derived intestinal epithelial cell monolayers were grown to capture immature progenitor-cell-promoting conditions for 7 days and maturation towards an enterocyte fate for 4 days. 3D enteroids in organoids growth media (OGM) included as control for a stem-cell rich phenotype.
ORGANISM(S): Homo sapiens (Human) 
2025-11-14 | PXD063020 | Pride
Differentiation Lc-msms Organoid Intestinal epithelium Epithelial cell 
UnknownEPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids.
Not available
S-EPMC10070114 | biostudies-literature
ProteomicsN-glycoproteomic analyses of human intestinal enteroids, varying in histo-blood group geno- and phenotypes, reveal a wide repertoire of fucosylated glycoproteins
Human noroviruses, globally the main cause of viral gastroenteritis, show strain specific affinity for histo-blood group antigens (HBGA) and can successfully be propagated ex vivo in human intestinal enteroids (HIEs). HIEs established from jejunal stem cells of individuals with different ABO, Lewis ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD046494 | Pride
Higher-energy collision dissociation Intestinal epithelium : glycoproteomics Host-pathogen interaction Histo-blood group antigens Human intestinal enteroids Fucosyltransferase Human norovirus Lc-ms/ms 
GenomicsINFANT AND ADULT HUMAN INTESTINAL ENTEROIDS ARE MORPHOLOGICALLY AND FUNCTIONALLY DISTINCT
INFANT AND ADULT HUMAN INTESTINAL ENTEROIDS ARE MORPHOLOGICALLY AND FUNCTIONALLY DISTINCT
PRJNA944129 | ENA
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