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Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
TranscriptomicsRecapitulation of human premature aging by using iPSCs from Hutchinson-Gilford progeria syndrome
Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature aging disease1-5, characterized by premature atherosclerosis and degeneration of vascular smooth muscle cells (SMCs)6-8. HGPS is caused by a single-point mutation in the LMNA gene, resulting in the generation of progerin...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-24487 | biostudies-arrayexpress
ProteomicsDevelopment of Cellular Energy Metabolism During Differentiation of Human iPSCs Into Cortical Neurons
We performed label-free quantitative proteomic profiling to characterize metabolic remodeling during early differentiation of human iPSCs into excitatory cortical neurons induced by NGN2 overexpression. Proteomic analysis was conducted at three time-points (iPSCs, day 7, and day 14 post-induction), ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD064787 | Pride
Human Lc-msms Ipscs Cell culture Neurons 
TranscriptomicsHypoxia-enhanced Derivation of iPSCs from Human Dental Pulp Cells
Hypoxia enhances the reprogramming efficiency of human dermal fibroblasts to become induced pluripotent stem cells (iPSCs). Because we showed previously that the hypoxia facilitates the isolation and maintenance of human dental pulp cells (DPCs), we examined here whether it promotes the reprogrammin...
ORGANISM(S): Homo sapiens 
2013-09-03 | E-GEOD-45872 | biostudies-arrayexpress
TranscriptomicsExpression data in induced pluripotent stem cells (iPSCs) derived from a DNA repair deficient fibroblast
Cockayne syndrome (CS) is an autossomal human disorder characterized by premature aging along with other symptoms. At the molecular level, CS is characterized by a deficiency in the Transcription-couple DNA repair pathway caused by a mutation mainly in ERCC6 gene and the absence of its functional pr...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-36648 | biostudies-arrayexpress
TranscriptomicsGene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48611 | biostudies-arrayexpress
ProteomicsGeneration and Proteome Profiling of PBMC-originated, iPSCs-derived Corneal Endothelial Cells
Corneal endothelial cells (CECs) are critical to maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cells (PBMC)-originated induced pluripotent stem cells (iPSCs)-derived CECs. We isolated PBMC and programmed the mononuclear cells to generate iPSCs. S...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD009142 | Pride
Mass-spectrometry Proteome Ipscs-derived corneal endothelial cells Pbmc 
TranscriptomicsInducible expression of MyoD directly mediates myogenic conversion of human induced pluripotent stem cells (iPSCs) derived from Duchenne muscular dystrophy (DMD).
Genome-wide gene expression analysis of MyoD-infected DMD-specific iPSCs (GM05112-M5.1) on days 0 (untreated), day 3 and day 8 post Dox treatment, human primary myoblasts (undifferentiated and as differentiated myotubes), and undifferentiated iPSCs from healthy donors (iPSCs-1 and iPSCs-2). DMD-spec...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-46633 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human induced pluripotent stem cells signature and memory retention
Transient expression of two factors, or from Oct4 alone, resulted in efficient generation of human iPSCs. The reprogramming strategy described revealed a potential transcriptional signature for human iPSCs yet retaining the gene expression of donor cells in human reprogrammed cells free of viral and...
ORGANISM(S): Homo sapiens 
2009-12-19 | E-GEOD-18618 | biostudies-arrayexpress
ProteomicsHuman iPSCs differentiated into SMCs
Human iPSCs were differentiated towards an induced-SMC (iSMC) phenotype in a 10-day protocol. Proteomics was performed throughout the entire differentiation time course to provide a robust, well-defined starting and ending cell population. Proteomics data verified iPSC differentiation to iSMCs. Prot...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032353 | Pride
Calcification Smooth muscle cell Lumos 
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