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MetabolomicsLiquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD) and 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone...
2023-11-28 | MTBLS2218 | MetaboLights
ProteomicsHuman liver homogenate, liver microsomes, low-speed centrifugation pellet and hepatocytes LC-MS/MS from 15 matched donors
LC-MS/MS-based label-free proteomics of human liver homogenate, human liver microsomes, and human hepatocytes from 15 matched donors used to compare and understand differences in two major in vitro systems used for drug metabolism studies
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD014131 | Pride
Human Low-speed centrifugation pellet Hepatocytes Liver Liver microsomes Lc-ms/ms 
ProteomicsProteomic Analysis of Human Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Homo sapiens (Human) 
2015-03-26 | PXD000721 | Pride
2d-lc-msms Tripletof Proteinpilot Human liver microsomes 
ProteomicsProteomic Analysis of Rat Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-26 | PXD000720 | Pride
2d-lc-msms Tripletof Rat liver microsomes Proteinpilot 
ProteomicsProteomic Analysis of Mouse Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Mus musculus (Mouse) 
2015-03-26 | PXD000731 | Pride
Mouse liver microsomes 2d-lc-msms Tripletof Proteinpilot 
ProteomicsSulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug Metaboing Enzymes as a Response to Redox Alteration
The lumen of the endoplasmic reticulum (ER) provides an oxidizing environment to aid in the formation of disulfide bonds, which is tightly regulated by both antioxidant proteins and small molecules. On the cytoplasmic side of the ER, cytochrome P450 (P450) proteins have been identified as a superfam...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-01-29 | PXD007913 | Pride
Human Dimedone Mouse Sulfenic acid Redox proteomics 
Proteomicsmouse liver microsomes phosphorylation with LC-MS/MS
The microsomes are re-formed vesicle-like artifacts, not ordinarily present in living cells, from pieces of the endoplasmic reticulum (ER), plasma membrane, mitochondria, and Golgi apparatus of broken eukaryotic cells. Typically, microsomes are separated by differential centrifuged from homogenized ...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD003043 | Pride
Tio2 Phosphorylation Mouse liver microsome Lc-ms/ms 
Proteomicsmouse liver microsomes phosphorylation
The microsomes are re-formed vesicle-like artifacts, not ordinarily present in living cells, from pieces of the endoplasmic reticulum (ER), plasma membrane, mitochondria, and Golgi apparatus of broken eukaryotic cells. Typically, microsomes are separated by differential centrifuged from homogenized ...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-24 | PXD002221 | Pride
Mouse Phosphorylation Microsome Liver 
ProteomicsQuantitative LC-MS/MS Proteomics of paediatric human liver microsomes
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 20 human liver microsomal samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020844 | Pride
Human Quantitative proteomics Paediatric livers Lc-ms/ms 
ProteomicsQuantitative LC-MS/MS Proteomics of human liver microsomes
We report label-free quantification of xenobiotic metabolizing enzymes (XME), transporters, redox enzymes, proteases and nucleases in 20 human liver microsomal samples. More than 3500 proteins were identified and quantified. These data can be used in physiologically based pharmacokinetic models to ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD020910 | Pride
Human Adult livers Quantitative proteomics Lc-ms/ms 
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