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MetabolomicsModulating the developing gut microbiota with 2’-fucosyllactose and pooled human milk oligosaccharides

Synthetic human milk oligosaccharide (HMO) structures are used to supplement infant formula despite limited understanding of their impact on the developing gut microbiota. Here, we assess the impact of 2-fucosyllactose (2’FL) and pooled (p)HMOs on the composition and activity of cultured microbia...

2024-09-03 | MTBLS9853 | MetaboLights
MetabolomicsChanges in the Milk Metabolome of the Giant Panda (Ailuropoda melanoleuca) with Time after Birth – Three Phases in Early Lactation and Progressive Individual Differences
Ursids (bears) in general, and giant pandas in particular, are highly altricial at birth. The components of bear milks and their changes with time may be uniquely adapted to nourish relatively immature neonates, protect them from pathogens, and support the maturation of neonatal digestive physiology...
2015-03-31 | MTBLS165 | MetaboLights
ProteomicsMucolytic activity of Akkermansia muciniphila enables Human Milk Oligosaccharides degradation.
This study was conducted in order to monitor whether or not Akkermansia muciniphila was able to grow and utilize human milk and human milk oligosaccharides by deploying its mucin degrading enzymes. Interestingly, A. muciniphila was able to grow in human milk producing Short Chain Fatty Acids and deg...
ORGANISM(S): Akkermansia muciniphila ATCC BAA-835 
2020-09-07 | PXD011357 | Pride
Human milk oligosaccharides Fucosyllactose Microbiota Akkermansia muciniphila Sialyllactose Early life 
ModelsIoannou2024 - Synthetic Human Infant Gut Microbial Community with Human Milk Oligosaccharides
These are genome-scale metabolic models used for understanding the metabolic activity and potential of a synthetic gut microbial community in the context of human milk oligossacharides.
2024-11-25 | MODEL2405300001 | BioModels
ProteomicsCortical Organoids Exposed to Human Milk Oligosaccharides
We verify the alterations the the proteome profile of organoids exposed to different concentrations of milk oligosaccharides.
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD064071 | Pride
Human milk Oligosaccharides Cortical organoids 
TranscriptomicsRNA sequencing of Bifidobacterium longum subsp. infantis in response to various substrates
The purpose of this project was to determine the whole transcriptome response of Bifidobacterium longum subsp. Infantis to pooled and individual human milk oligosaccharides (HMO) relative to lactose Bacterial isolates grown on lactose, pooled human milk oligosaccharides (HMO), lacto-N-tetraose (LNT)...
ORGANISM(S): Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 
2015-10-28 | E-GEOD-58773 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of Bifidobacterium bifidum SC555 in response to various substrates
The purpose of this project was to determine the whole transcriptome response of Bifidobacterium bifidum SC555 to pooled and individual human milk oligosaccharides (HMO) relative to lactose Bacterial isolates grown on lactose, pooled human milk oligosaccharides (HMO), lacto-N-tetraose (LNT), lacto-N...
ORGANISM(S): Bifidobacterium bifidum 
2015-10-28 | E-GEOD-59053 | biostudies-arrayexpress
ProteomicsHuman milk oligosaccharides and infant fecal oligosaccharides
In this study, we quantitated the disappearance of intact HMOs and characterized the glycan digestion products in the gut that are produced by the action of microbial enzymes on HMOs and glycoconjugates from breast milk. Oligosaccharides from fecal samples of exclusively breast-fed infants were extr...
ORGANISM(S): Homo sapiens (Human) 
2016-07-26 | PXD004434 | Pride
Liquid chromatography Oligosaccharide Feces Mass spectrometry Milk 
ProteomicsPeptidomics analysis of milk protein-derived peptides released over time in the preterm infant stomach
Over the course of milk digestion, native milk proteases and infant digestive proteases fragment intact proteins into peptides with potential bioactivity. This study investigated the release of peptides over three hours of gastric digestion in 14 preterm infant sample sets. The peptide content was e...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2019-03-12 | PXD012192 | Pride
Gastric Human milk Preterm Digestion Peptide Bioactive 
TranscriptomicsIn vitro transcriptional profiling of Bacteroides thetaiotaomicron in lactose, galactose and human milk oligosaccharides
Investigation of the overall in vitro response of Bacteroides thetaiotaomicron to human milk oligosaccharides. Comparison with response to MM-lactose and MM-galactose (Analysis performed using as a baseline datasets GSM301635 and GSM301637 corresponding to Bacteroides thetaiotaomicron response in MM...
ORGANISM(S): Bacteroides thetaiotaomicron 
2013-01-01 | E-GEOD-26772 | biostudies-arrayexpress
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