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ProteomicsThe potential role of extracellular vesicles derived from human myogenic precursor cells
The physiological decline in skeletal muscle mass, power and function, known as sarcopenia, presents significant challenges for aged subjects. Recently, skeletal muscle is recognised as a se-cretory organ as human myogenic precursor cells (hMPCs) can release extracellular vesicles (EVs). This work a...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-24 | PXD063794 | Pride
Extracellular vesicles Mirna Human myogenic precursor cells 
TranscriptomicsEbf2 is a selective marker of brown and beige adipogenic precursor cells (RNA-seq)
Brown adipocytes, muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic p...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-60441 | biostudies-arrayexpress
TranscriptomicsInducible expression of MyoD directly mediates myogenic conversion of human induced pluripotent stem cells (iPSCs) derived from Duchenne muscular dystrophy (DMD).
Genome-wide gene expression analysis of MyoD-infected DMD-specific iPSCs (GM05112-M5.1) on days 0 (untreated), day 3 and day 8 post Dox treatment, human primary myoblasts (undifferentiated and as differentiated myotubes), and undifferentiated iPSCs from healthy donors (iPSCs-1 and iPSCs-2). DMD-spec...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-46633 | biostudies-arrayexpress
TranscriptomicsmiR-487b, miR-3963 and miR-6412 delayed myogenic differentiation in C2C12 mouse myoblast-derived cells.
We newly identified skeletal muscle differentiation-associated miRNAs by comparing miRNA expression profile between C2C12 cell and Wnt4-overexpressing C2C12 cell. miR-487b, miR-3963 and miR-6412 are significantly down-regulated in differentiating C2C12 cells, and transfection of their mimics result...
ORGANISM(S): Mus musculus 
2015-11-24 | E-GEOD-63454 | biostudies-arrayexpress
TranscriptomicsEbf2 is a selective marker of brown and beige adipogenic precursor cells (Microarray)
Brown adipocytes, muscle and dorsal dermis descend from precursor cells in the dermomyotome, but the factors that regulate commitment to the brown adipose lineage are unknown. Here, we prospectively isolated and determined the molecular profile of embryonic brown preadipose cells. Brown adipogenic p...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-60442 | biostudies-arrayexpress
TranscriptomicsIsolation of human skeletal muscle precursor cells by fluorescence-activated cell sorting.
Novel fluorescence-activated cell sorting (FACS) strategies to prospectively purify functionally distinct cell populations from the human myofiber-associated (hMFA) cell compartment, including human Skeletal Muscle Precursor cells (hSMPs): HSMPs, identified as CD45-Mac1-GlyA-CD31-CD34-CD56intITGA7hi...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-44227 | biostudies-arrayexpress
TranscriptomicsDistant cis Regulation of Myogenic Differentiation
Identifying tissue and condition-specific gene regulatory elements and the mechanisms by which they associate with their target genes in human cells remains a significant challenge, largely due to the vast amount of non-protein-coding sequence in the human genome. Despite increasing evidence of phys...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-29865 | biostudies-arrayexpress
TranscriptomicsA Pitx2-miRNA pathway modulates cell proliferation in myoblasts and skeletal-muscle satellite cells and promotes their commitment to a myogenic cell fate.
The acquisition of a proliferating cell status from a quiescent state as well as the shift between proliferation and differentiation are key developmental steps in skeletal-muscle stem cells (satellite cells) to provide proper muscle regeneration. However, how satellite-cell proliferation is regulat...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-53943 | biostudies-arrayexpress
TranscriptomicsHuman iPSC-based model for Duchenne muscular dystrophy
We developed a novel somite-based step-wise strategy for the efficient derivation of functional human myocytes, suggesting that past failures were due to incomplete specification. Treatment with two small molecules inhibiting glycogen synthase kinase 3β (GSK-3β) and the Notch signaling pathway in ...
ORGANISM(S): Homo sapiens 
2016-06-16 | E-GEOD-70955 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 4q-linked and phenotypic FSHD in different steps of myogenic differentiation
The specific gene(s) responsible for FSHD phenotype have not yet been identified. We used the Human GeneChip Exon 1.0 ST platform to analyze the global gene expression profiles of FSHD-1, FSHD-2 and controls during myogenic differentiation. In this dataset, we include the expression data of human pr...
ORGANISM(S): Homo sapiens 
2011-07-07 | E-GEOD-26061 | biostudies-arrayexpress
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