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ProteomicsHuman p11-mediated re-direction of phagosomes to the recycling endosome-expulsion pathway induced by fungal pathogen
Aspergillus fumigatus invades pulmonary epithelial cells by induced phagocytosis, and survives for some time in phagosomes. Although dihydroxynaphthalene melanin on fungal conidia has been intensively investigated for its role in inhibiting phagosome maturation, a proportion of melanin-lacking mutan...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Homo sapiens (Human) 
2023-03-13 | PXD030501 | Pride
Recycling endosome Exocytosis Pathogen Human p11 Rab7 Phagosome maturation Heat shock protein Anxa2 Rab11 
TranscriptomicsEffect of fluoxetine treatment on translational profiles of S100a10 cortical pyramidal cells in p11 KOs
Molecular phenotyping of cell types and neural circuits underlying pathological neuropsychiatric conditions and their responses to therapy provides one avenue for the development of more specific and effective treatments. In this study, we identify a cell population in the cerebral cortex that shows...
ORGANISM(S): Mus musculus 
2012-05-31 | E-GEOD-35765 | biostudies-arrayexpress
MetabolomicsInnate Immune Training of Human Macrophages by Cathelicidin Analogs
Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...
2022-07-11 | MTBLS4495 | MetaboLights
ProteomicsMass spectrometric ITEM-TWO analyses of interactions between human cardiac Troponin T (hcTnT) peptides and the M7 or the M11.7 antiTnT antibodies.
Molecular characterization of antibodies M7, and M11.7, as well as the antiTNF alpha antibody in addition to the synthetic peptides P11-P17 and P21-P32. The M7 and M11.7 anti-human cardiac Troponin T (antihcTnT) antibodies from Roche Diagnostics Deutschland GmbH (Mannheim, Germany) and the antiTNF a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-20 | PXD058812 | Pride
Item-two Troponin t Offline nanoesi-ms 
GenomicsHuman p11-mediated re-direction of phagosomes to the recycling endosome-expulsion pathway by a fungal pathogen
Human p11-mediated re-direction of phagosomes to the recycling endosome-expulsion pathway by a fungal pathogen
PRJNA901357 | ENA
TranscriptomicsHuman p11-mediated re-direction of phagosomes to the recycling endosome-expulsion pathway by a fungal pathogen
The decision whether endosomes in mammalian cells enter the degradative or non-degradative pathway is of fundamental importance for killing of ingested pathogens and an essential basic mechanism whose malfunctioning has pathological consequences. We discovered that the human p11 protein is a decisiv...
ORGANISM(S): Homo sapiens 
2023-03-08 | GSE217895 | GEO
UnknownAspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway.
Not available
S-EPMC10016320 | biostudies-literature
MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
UnknownElevation of p11 in lateral habenula mediates depression-like behavior.
Not available
S-EPMC5690885 | biostudies-literature
UnknownReversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens.
Not available
S-EPMC3026098 | biostudies-literature
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