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TranscriptomicsIndoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress
ProteomicsHuman podocyte cell culture degradomics
Regulated intracellular proteolysis is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. Altered proteolytic substrate turnover has been associated with various glomerular diseases ranging from diabetic nephropathy to focal and segmental glomeru...
ORGANISM(S): Homo sapiens (Human) 
2017-07-20 | PXD005140 | Pride
Human podocyte cell culture Tails Pan challenge 
TranscriptomicsComparison of Glomerular and Podocyte mRNA Profiles in eNOS-/- Diabetic Mice Induced by Streptozotocin
We compared mRNA profiles of isolated glomeruli versus sorted podocytes between diabetic and control mice. IRG mice crossed with eNOS-/- mice were further bred with podocin-rTTA and TetON-Cre mice to permanently label podocytes before the diabetic injury. Diabetes was induced by injection of strepto...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-79291 | biostudies-arrayexpress
ProteomicsPodocyte Focal Adhesion Proteome
Expression proteomics analysis of focal adhesion complexes isolated from a human immortalized podocyte cell line.
ORGANISM(S): Homo sapiens (Human) 
2018-12-14 | PXD010626 | Pride
Human Podocyte Glomerulus Kidney Lc-ms/ms 
GenomicsGlucocorticoid receptor ChIP-seq in an immortalized podocyte cell line
The identification of the glucocorticoid receptor cistrome in a conditionally immortalized human podocyte cell line developed by transfection with the temperature-sensitive SV40-T gene
ORGANISM(S): Homo sapiens 
2017-07-17 | E-MTAB-5238 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid therapy regulates podocyte motility by inhibition of Rac1
Nephrotic syndrome (NS) occurs when the glomerular filtration barrier becomes excessively permeable leading to massive proteinuria. In childhood NS, dysregulation of the immune system has been implicated and increasing evidence points to the central role of podocytes in the pathogenesis. Children wi...
ORGANISM(S): Homo sapiens 
2017-07-17 | E-MTAB-5235 | biostudies-arrayexpress
TranscriptomicsGene expression in a conditionally immortalized mouse podocyte cell line
The specialized glomerular epithelial cell (podocyte) of the kidney is a complex cell that is often damaged in glomerular diseases. Study of this cell type is facilitated by an in vitro system of propagation of conditionally immortalized podocytes. Here, genes that are differentially expressed in th...
ORGANISM(S): Mus musculus 
2010-08-28 | E-GEOD-23856 | biostudies-arrayexpress
TranscriptomicsCo-culture of human hematopoietic stem cells with osteoblasts affects mono/macrophage versus erythroid lineage choice.
Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs interact with a variety of stromal cells. Though several components of the stem cell niche have been identified, the regulatory mechanisms through w...
ORGANISM(S): Homo sapiens 
2013-05-10 | E-GEOD-38091 | biostudies-arrayexpress
TranscriptomicsEffect of Growth hormone on podocytes
Transcriptome analysis of growth hormone dependant genes in glomerular podocytes Differentiated human glomerular podocytes in culture exposed to growth hormone for 0 min, 2 min, 5 min, 15 min, and 30 min. Total RNA is extracted and subjected to microarray analysis.
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-21327 | biostudies-arrayexpress
ProteomicsAnalysis of the cultured podocyte phosphoproteome
The renal filtration barrier is critically maintained by the renal podocyte, a postmitotic, neuron-like epithelial cell type. Cultured podocyte cell lines – both in the differentiated and undifferentiated state - are a widely utilized tool to estimate cytoskeletal rearrangement processes in vitro. H...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-04 | PXD004013 | Pride
Podocyte Cell culture Kidney Mouse 
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