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ProteomicsDevelopment and Comparative Evaluation of Endolysosomal Proximity Labeling-based Proteomic Methods in Human iPSC-derived Neurons
Proximity-based in situ labeling techniques offer a unique way to capture both stable and transient protein-protein and protein-organelle interactions. Combining this technology with mass spectrometry (MS)-based proteomics allows us to obtain snapshots of molecular microenvironments with nanometer r...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-10-10 | MSV000086260 | MassIVE
ProteomicsA Proximity Labeling Strategy Enables Spatial Proteomic Analysis of Inter-organelle Membrane Contacts in Living Cells
Inter-organelle membrane contacts especially mitochondria-endoplasmic reticulum contacts (MERC) conduct important biological functions including exchange of lipids and ions, and modulation of membrane dynamics. Alterations of inter-organelle membrane contacts have been implicated with the pathogenes...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035801 | Pride
Apex Bifc Merc Proteome 
UnknownDevelopment and Comparative Evaluation of Endolysosomal Proximity Labeling-Based Proteomic Methods in Human iPSC-Derived Neurons.
Not available
S-EPMC8895409 | biostudies-literature
ProteomicsProximity proteomics of endothelial Weibel-Palade bodies identifies novel regulator of VWF secretion
Weibel-Palade bodies (WPB) are unique secretory organelles of endothelial cells that store factors regulating vascular haemostasis and local inflammation. Endothelial activation triggers the acute exocytosis of WPB, leading to the surface presentation of adhesion molecules relevant for leukocyte rol...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD013194 | Pride
Lc-msms Weibel-palade bodies Von-willebrand factor Endothelial cells Proximity labeling Human Biotinylation 
ProteomicsMicroID: A Novel Biotin Ligase Enables Rapid Proximity Ligation Proteomics
Identifying protein-protein interactions is central to dissecting signaling and regulatory processes in cells. BioID is a proximity ligation method that uses a promiscuous biotin ligase to detect protein-protein interactions in cells in a highly reproducible manner. Recent advancements in proximity ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031146 | Pride
Proximity ligation  bioid  turboid  organelle  mass spectrometry  microid 
ProteomicsA Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of mitochondria-lipid droplet contact proteomes
Accumulating studies have shown that mitochondria-lipid droplet (LD) interaction is crucial for maintaining the homeostasis of lipid metabolism in the liver. However, the proteins involved in mitochondria-LD interaction and the functioning mechanism remain largely elusive. Here, we applied a systema...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035813 | Pride
Cholesterol Bifc Comparative proteomics Proximity labeling Mitochondria-lipid droplet contact 
ProteomicsPRM quantification of MCS proteins and viral proteins in HCMV virus microenvironment
The control of host processes which influence cell-cell communication is central to determining the outcome of a virus infection in tissue. Despite this, it remains unclear how cells either in close or distant proximity to an infected cell differentially respond to the primary infection. We establis...
ORGANISM(S): Homo Sapiens Human Betaherpesvirus 5 
PXD038466 | panorama
ProteomicsProximity labeling on phosphatidic acid-enriched membranes generated via optogenetic membrane editing
Cellular lipid metabolism is subject to strong homeostatic regulation, but players involved in and mechanisms underlying these pathways remain mostly uncharacterized. Here, we develop and exploit a “Feeding-Fishing” approach coupling membrane editing using optogenetic lipid-modifying enzymes (feedin...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD070378 | Pride
Feeding-fishing Membrane-turboid Optopld Membrane editing Phospholipase d Phosphatidic acid 
ProteomicsProximity labeling on phosphatidic acid-enriched membranes generated via optogenetic membrane editing (set2)
Cellular lipid metabolism is subject to strong homeostatic regulation, but players involved in and mechanisms underlying these pathways remain mostly uncharacterized. Here, we develop and exploit a “Feeding-Fishing” approach coupling membrane editing using optogenetic lipid-modifying enzymes (feedin...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD070270 | Pride
Feeding-fishing Membrane-turboid Optopld Membrane editing Phospholipase d Phosphatidic acid 
ProteomicsCLUH interactome reveals its association to SPAG5 and its proximity to the translation of mitochondrial proteins
Mitochondria require thousands of proteins to fulfil their essential function in energy production and other fundamental biological processes. These proteins are mostly encoded by the nuclear genome, translated in the cytoplasm before being imported into the organelle. RNA binding proteins (RBPs) ar...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-12-13 | PXD027158 | Pride
Cluh Turboid Rna binding protein Mitochondrial proteins Bioid 
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