Sort   by:  
 Page size 
ProteomicsInhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors
We conducted global proteome and phosphoproteome profiling of vehicle- and everolimus-treated tumors from 17 mice that were allografted with spontaneously developed mammary tumors from Brca1co/coMMTV-Cre mice using LC-MS/MS. The Proteome Discoverer analysis identified 9,625 proteins having two uniqu...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-24 | PXD054301 | Pride
Everolimus Brca1 Lc-ms/ms 
ProteomicsDisruption of nucleocytoplasmic trafficking as a cellular senescence driver
Senescent cells exhibit a reduced response to intrinsic and extrinsic stimuli. This reduction could be explained by disrupted nuclear transmission of signals. However, this hypothesis required more evidence to complete as a new modality of cellular senescence. Proteomic analysis of the cytoplasmic a...
ORGANISM(S): Homo sapiens (Human) 
2021-06-18 | PXD025618 | Pride
Nuclear barrier Cellular senescence Replicative senescence Eukaryotic aging Nucleocytoplasmic trafficking 
TranscriptomicsA novel NAC transcription factor cooperates with bZIP-type transcription factors in dehydration and osmotic stress responses
Multiple transcription factors (TFs) play essential roles in plants under abiotic stress, one of the most challenging conditions of plant survival. However, how these multiple TFs cooperate in abiotic stress responses still remains largely unknown. In this study, we provide evidence that a novel NAC...
ORGANISM(S): Arabidopsis thaliana 
2014-01-02 | E-GEOD-51218 | biostudies-arrayexpress
ProteomicsPhosphoproteome of Thylakoid membrane in leaf senescence
Here, we investigated the role of STN7 kinase of photosynthetic protein complexes in leaf senescence. Defects in STN7 accelerated leaf yellowing and decreased the efficiency of leaf photosynthetic complexes. To identify STN7 targets, we profiled global proteomes and phosphoproteomes of thylakoid mem...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-12-08 | PXD033330 | Pride
Thylakoid membrane Photosynthetic protein complexes Leaf senescence Stn7 Lfnr2 
ProteomicsGlobal proteome of Thylakoid membrane in leaf senescence
Here, we investigated the role of STN7 kinase of photosynthetic protein complexes in leaf senescence. Defects in STN7 accelerated leaf yellowing and decreased the efficiency of leaf photosynthetic complexes. To identify STN7 targets, we profiled global proteomes and phosphoproteomes of thylakoid mem...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-12-08 | PXD033333 | Pride
Thylakoid membrane Photosynthetic protein complexes Leaf senescence Stn7 Lfnr2 
ProteomicsA secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cell line
Increased fatty acid (FA) is often observed in highly proliferative tumors, contributing to promoting proliferation of tumor cells. FA affects secreted factors from tumor cells, which can modulate tumor microenvironment in favor of tumor survival. However, the secreted factors affected by the increa...
ORGANISM(S): Homo sapiens (Human) 
2018-08-08 | PXD007906 | Pride
Human Hepatocellular carcinoma Oleate Hepg2 
ProteomicsProteogenomic characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling
Hyperactivated mTOR signaling in the developing brain by mutation of TSC1 genes has multiple forms of pathology including tuberous sclerosis complex (TSC). To examine the downstream networks affected in the developing brain by hyperactivated mTOR signaling, we performed an integrated analysis of tra...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-16 | PXD005768 | Pride
Lc-msms Mouse Brain Forebrain 
TranscriptomicsGene duplication of type-B ARR transcription factors systematically extends transcriptional regulatory structures in Arabidopsis
Many of duplicated genes are enriched in signaling pathways. Recently, gene duplication of kinases has been shown to provide genetic buffering and functional diversification in cellular signaling. Transcription factors (TFs) are also often duplicated. However, how duplication of TFs affects their re...
ORGANISM(S): Arabidopsis thaliana 
2015-02-03 | E-GEOD-62597 | biostudies-arrayexpress
UnknownDDM1-mediated gene body DNA methylation is associated with inducible activation of defense-related genes in Arabidopsis.
Not available
S-EPMC10161647 | biostudies-literature
TranscriptomicsNFAT5 is a critical regulator of rheumatoid inflammation
NFAT5 is an osmoprotective transcription factor whose DNA binding domain shares structural homology with NFkappaB and other member of NFAT family, but its role in chronic inflammatory diseases remains unclear. The mRNA profiling of synoviocytes and endothelial cells transfected with NFAT5-targeted s...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-GEOD-22956 | biostudies-arrayexpress
Sort   by:  
 Page size