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ProteomicsRDEB Mouse Model - Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms
Expression proteomics of back skin of collagen VII (C7) hypomorphic and WT mice was performed to detect differences in the skin proteome dependent on the presence of collagen VII and the treatment with losartan.
ORGANISM(S): Mus musculus (Mouse) 
2015-10-02 | PXD002134 | Pride
Lc-msms Collagen vii Epidermolysis bullosa Hypomorphic mouse Skin Losartan 
TranscriptomicsNext Generation Sequencing Analysis of Wild Type and Hypomorphic Nkx2-5 mutant heart Transcriptomes
We report the transcriptome analysis of E11.5 mouse embryonic heart presenting a reduction in Nkx2-5 expression compare to wild-type littermate. Transcriptome analysis of 3 different E11.5 hypomorphic hearts against 3 controls littermate hearts.
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-44573 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wildtype lungs vs. lung hypomorphic for nmyc
comparison of expression of wildtype lungs and lungs with hypomorphic expression of nmyc. the lungs were pooled from several biological samples. The hypomorphoic mutant was orignally published in Moens CB et al [PMID: 1577267]. this is part of a larger collection of data comparing nmyc misexpression...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6079 | biostudies-arrayexpress
TranscriptomicsDeregulated expression programs in the hypomorphic Dnmt3b mutant mice
The function of Dnmt3b, of which deregulated activity is linked to several human pathologies, was studied using Dnmt3b hypomorphic mutant mice with reduced catalytic activity. Microarray analysis of deregulated expression programs in the hypomorphic Dnmt3b mutant mice (m3/m24) was combined to an ana...
ORGANISM(S): Mus musculus 
2010-04-21 | E-GEOD-19597 | biostudies-arrayexpress
GenomicsSupression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic spo11 allele
Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA bin...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-48493 | biostudies-arrayexpress
TranscriptomicsMouse embryo heart, e10.5 AVC: Control vs. Tbx3 hypomorphic mutant
Transcriptional profiling of the atrioventricular canal from e10.5 mouse hearts comparing wild-type control with Tbx3 GH/N hypomorphic mutant microdissected tissue. The goal was to identify direct and indirect targets of the transcription factor Tbx3, because Tbx3 is expressed in the AVC and hypomor...
ORGANISM(S): Mus musculus 
2011-04-01 | E-GEOD-24122 | biostudies-arrayexpress
ProteomicsLow kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones
Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist mainly of densely packed podosomes tightly inter-connected by actin fibers. Their formation requires the presence of the hematopoietic integrin reg...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD026711 | Pride
Sealing zone Podosome Osteoclast Bone resorption Kindlin-3 Integrin 
TranscriptomicsMouse embryo heart, e10.5 AVC: Control vs. Tbx3 hypomorphic mutant
Transcriptional profiling of the atrioventricular canal from e10.5 mouse hearts comparing wild-type control with Tbx3 GH/N hypomorphic mutant microdissected tissue. The goal was to identify direct and indirect targets of the transcription factor Tbx3, because Tbx3 is expressed in the AVC and hypomor...
ORGANISM(S): Mus musculus 
2011-04-01 | GSE24122 | GEO
GenomicsPartial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations
Partial correction of immunodeficiency by lentiviral vector gene therapy in mouse models carrying Rag1 hypomorphic mutations
PRJEB65467 | ENA
UnknownHypomorphic mutation of the mouse Huntington's disease gene orthologue.
Not available
S-EPMC6445486 | biostudies-literature
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