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TranscriptomicsGene expression profiling of aortic media after long-term treatment with an angiotensin II-receptor blocker, Losartan
Rats (Wag/Rij, females) were chronically treated with Losartan (20mg/d), an angiotensin II-receptor blocker during 9 months. Gene expression profiling was performed on aortic media to understand the long-term effect of this molecule on the cardiovascular system. Two-conditions experiment, Ctrl vs Lo...
ORGANISM(S): Rattus norvegicus 
2010-09-23 | E-GEOD-18298 | biostudies-arrayexpress
ProteomicsRDEB Mouse Model - Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms
Expression proteomics of back skin of collagen VII (C7) hypomorphic and WT mice was performed to detect differences in the skin proteome dependent on the presence of collagen VII and the treatment with losartan.
ORGANISM(S): Mus musculus (Mouse) 
2015-10-02 | PXD002134 | Pride
Lc-msms Collagen vii Epidermolysis bullosa Hypomorphic mouse Skin Losartan 
TranscriptomicsAngiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in a murine model
TGFβ inhibition attenuates chronic cigarette smoke induced lung injury and rescues lung architecture. AKR/J mice were exposed to Cigarette Smoke (CS) for a period of two months. Some animals received a treatment of Losartan (.6gr/L) orally while exposed (CS Los). These two groups are to be compare...
ORGANISM(S): Mus musculus 
2011-12-30 | E-GEOD-33561 | biostudies-arrayexpress
ModelsKaratzaKaralis2020 - CYP mediated losartan metabolism
A four-compartment pharmacokinetic model that describes the disposition of losartan and E-3174 (Karatza and Karalis, 2020). The main objective of this model is to describe the secondary maxima observed in the plasma concentration-time profiles of losartan and E-3174. This model incorporates a sinuso...
2025-12-24 | MODEL2412180001 | BioModels
TranscriptomicsExpression data from mouse kidney tissue
The role of the renin-angiotensin system in chronic kidney disease involves multiple peptides and receptors. Exerting antipodal pathophysiological mechanisms, renin inhibition and AT1 antagonism ameliorate renal damage. This is a comparison between the renin inhibitor aliskiren with the At1 antagoni...
ORGANISM(S): Mus musculus 
2012-11-05 | E-GEOD-34552 | biostudies-arrayexpress
ModelsBabaev2025 - CYP2C9 and ABCB1 losartan metabolism model
The model can simultaneously predict the profiles of both losartan and its active metabolite, E-3174, based on a given patient's CYP2C9 and ABCB1 genotypes. The CYP2C9 alleles considered are CYP2C9*1 and CYP2C9*3; the ABCB1 alleles considered are 2677G, 2677T, 3435C, and 3435T. The model includes fi...
2025-09-08 | MODEL2504020001 | BioModels
TranscriptomicsGene expression regulation by angiotensin II in late gestation fetal sheep
We undertook a transcriptome-wide discovery approach to provide information on the involved gene regulatory responses to change in fetal cardiac mass in response to chronic infusion of angiotensin II or losartan. One of each of 8 twin fetus pairs was infused with either angiotensin II or losartan da...
ORGANISM(S): Ovis aries 
2013-08-09 | E-GEOD-45463 | biostudies-arrayexpress
GenomicsExpression data from kidney tissues treated with vehicle, losartan and metformin
Expression data from kidney tissues treated with vehicle, losartan and metformin
PRJNA432213 | ENA
GenomicsLosartan Effects on Emphysema Progression (LEEP-BioLINCC)
Losartan Effects on Emphysema Progression (LEEP-BioLINCC)
PRJNA1328212 | ENA
GenomicsLosartan Effects on Emphysema Progression (LEEP-BioLINCC)
Losartan Effects on Emphysema Progression (LEEP-BioLINCC)
PRJNA1328214 | ENA
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