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MetabolomicsHypothalamic SLC7A14 accounts for aging-reduced lipolysis in white adipose tissue

The central nervous system has been implicated in the age-induced reduction in adipose tissue lipolysis. SLC7A14 is a lysosomal membrane protein highly expressed in the brain. Herein, we investigated the possible role of hypothalamic SLC7A14 in the age-induced lipolysis reduction. In this study, ...

2024-07-23 | MTBLS9872 | MetaboLights
TranscriptomicsIdentification of the hypothalamic neuronal populations that derive from Pomc-expressing precursors
Hypothalamic neuronal populations are central regulators of energy homeostasis and reproductive function. However, the ontogeny of these critical hypothalamic neuronal populations is largely unknown. Here, we reveal novel cellular fates of the hypothalamic Pomc-expressing precursors by combining mou...
ORGANISM(S): Mus musculus 
2015-04-16 | E-GEOD-56917 | biostudies-arrayexpress
ProteomicsPeptidomics of Human Hypothalamic neurons
The study of peptide secretion, and identifying its control requires the use of ELISAs for measuring their levels pre and post stimulation. In place of ELISA's an LC-MS methdology was developed first to identify the correct peptides generated by the neurons, which could then be used to measure the p...
ORGANISM(S): Homo sapiens (Human) 
2018-08-22 | PXD008795 | Pride
Peptidomics Pomc Hypothalamic neurons 
TranscriptomicsTranscription profiling of human hypothalamic hamartomas (HH) obtained from patients with or without precocious puberty (CPP)
Hypothalamic hamartomas (HHs) are congenital lesions of the neuroendocrine brain composed of neurons and astroglia. Frequently, HHs are associated with central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal pu...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7142 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis of hypothalamic GT1-7 neurons
To elucidate the mechanism of neuronal activation, we conducted a global quantitative phosphoproteomic analysis of hypothalamic neurons treated with Raptin or PBS. By COG analysis of the differentially expressed phosphorylation protein, we found obvious alterations of transport and catabolism, as we...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-27 | PXD059980 | Pride
Phosphoprotemics Mice Gt1-7 cells 
TranscriptomicsMolecular profiling of hypothalamic leucine-sensing neurons via PhosphoTRAP
To identify the molecular signature of leucine-activated neurons in the MBH, we adopted the PhosphoTRAP assay following parenchymal injection of leucine into the MBH. Neurons activated following MBH leucine injection (and expressing the neuronal activation marker cFos) co-express Ser240/244-phospho...
ORGANISM(S): Mus musculus 
2026-04-01 | E-MTAB-16665 | biostudies-arrayexpress
TranscriptomicsGene expression profiling (RNA-seq) of SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for RNA-seq at several differentiation stages. The differentiations were performed in one biological replicate, with three technical replicates (different...
ORGANISM(S): Homo sapiens 
2021-05-22 | E-MTAB-10461 | biostudies-arrayexpress
TranscriptomicsOpen chromatin profiling (ATAC-seq) of SGBS human preadipocytes (days 0, 2, 8 and 16 of differentiation to adipocytes) and iPSC-derived hypothalamic neurons (days 12, 16 and 27 of differentiation)
Human SGBS preadipocytes were differentiated into adipocytes, and human iPSCs were differentiated into hypothalamic neurons. Cells were collected for ATAC-seq at several differentiation stages. The differentiations were performed in one biological replicate, with two technical replicates (different ...
ORGANISM(S): Homo sapiens 
2021-05-22 | E-MTAB-10462 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary rat hypothalamic neurons by short- and long-term estrogen stimulation and withdrawal
Postpartum depression (PPD) is a prevalent neuroendocrine disorder triggered by the abrupt decline of estrogen after delivery. Estrogen withdrawal after delivery profoundly influences neurotransmission, synaptic plasticity, and neuroendocrine function within the hypothalamic pituitary gonadal (HPG) ...
ORGANISM(S): Rattus norvegicus 
2026-01-31 | E-MTAB-16415 | biostudies-arrayexpress
GenomicsTBX3 defines the functional identity of hypothalamic melanocortin neurons
TBX3 defines the functional identity of hypothalamic melanocortin neurons
PRJNA490554 | ENA
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