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ProteomicsIgA deglycosylation to identify glycosylation sites
In order to provide information on the peptide sequence of the IgA glycopeptides, a proteomics analysis was run on LC-MS/MS data of N-glycosidase F-digested IgA samples, in which the N-glycans had been released. The samples included IgA (isolated) from: 1) the saliva samples from two healthy donors,...
ORGANISM(S): Homo sapiens (Human) 
2018-11-09 | PXD011228 | Pride
Iga Secretory iga Plasma Colostrum Saliva 
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we show that dimeric IgA, but not the same antibody on ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042914 | Pride
Transcytosis Cancer Therapeutic antibodies Immunoglobulin a 
ProteomicsOxonium ion scanning mass spectrometry for large-scale plasma glycoproteomics
Protein glycosylation, a complex and heterogeneous post-translational modification that is frequently dysregulated in disease, has been difficult to analyse at scale. Here we report a data-independent acquisition technique for the large-scale mass-spectrometric quantification of glycopeptides in pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-29 | MSV000089567 | MassIVE
ProteomicsIdentification of salivary autoantibodies as biomarkers of oral cancer with IgA enrichment combined with affinity mass spectrometry
Globally, oral cavity squamous cell carcinoma (OSCC) is one of the most common fatal illnesses. Its high mortality is ascribed to the fact that the disease is often diagnosed at a late stage, which indicates an urgent need for approaches for the early detection of OSCC. The use of salivary autoantib...
ORGANISM(S): Homo sapiens (Human) 
2025-06-04 | PXD036897 | Pride
Autoantibody Proteomics Saliva Biomarker Oral cavity squamous cell carcinoma 
UnknownIgA Structure Variations Associate with Immune Stimulations and IgA Mesangial Deposition.
Not available
S-EPMC5004660 | biostudies-literature
UnknownCarboxymethyl-lysine is a Prominent Target of Circulating IgA in IgA Nephropathy.
Not available
S-EPMC12266160 | biostudies-literature
GenomicsChromatin remodeling in HIF-1a deficient B cell during IgA class switching [ChIP-seq]
The interconnection between metabolic programming and chromatin remodeling during IgA class switching suggest that HIF-1a-dependent glycolytic flux may control the epigenetic modification at α class switching region (Sα) in the Igh locus. To test our hypothesis, histone acetylation was analyzed by c...
ORGANISM(S): Mus musculus 
2025-01-08 | GSE228366 | GEO
GenomicsChromatin remodeling in HIF-1a deficient B cell during IgA class switching [ChIP-seq]
Chromatin remodeling in HIF-1a deficient B cell during IgA class switching [ChIP-seq]
PRJNA949562 | ENA
UnknownMicrobiota, IgA and Multiple Sclerosis.
Not available
S-EPMC8954136 | biostudies-literature
UnknownDeciphering roles of protein post-translational modifications in IgA nephropathy progression and potential therapy.
Not available
S-EPMC10817402 | biostudies-literature
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