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MetabolomicsMetabolomics of immunoglobulin-producing cells in IgA nephropathy
Not available
ORGANISM(S): Homo sapiens 
ST000560 | MetabolomicsWorkbench
TranscriptomicsTranscriptomic and proteomic profiling reveal insights of mesangial cell function in patients with IgA Nephropathy
IgA nephropathy (IgAN) is the most common glomerulonephritis in the world. The disease is characterized by galactose deficient IgA (gd-IgA) in the circulation forming immune complexes. The complexes are deposited in the glomerular mesangium leading to inflammation and loss of renal function, but the...
ORGANISM(S): Homo sapiens 
2017-07-03 | E-GEOD-93798 | biostudies-arrayexpress
GenomicsIgA Nephropathy GWAS (IGANGWAS)

We report a genome-wide association study of IgA nephropathy, a main cause of kidney failure. All subjects were of Chinese Han ancestry, of which 1,194 were cases and 902 controls. Genomic DNA samples extracted from whole blood were genotyped on the Illumina 610 Quad platform.

phs000431.v1.p1 | EGA
GenomicsHLA has strongest association with IgA nephropathy in genome-wide analysis
GWAS study of families with probands with IgA nephropathy from the UK Glomerulonephritis DNA bank
EGAS00000000031 | EGA
TranscriptomicsAltered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy
To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects, We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I)...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-14795 | biostudies-arrayexpress
TranscriptomicsThe molecular phenotype of endocapillary proliferation in IgA nephropathy and potential modulation by bioactive small molecules
Endocapillary proliferation is associated with higher risk of progressive disease in IgAN. To better understand molecular pathways involved in the development of endocapillary proliferation and to identify novel specific therapeutic targets, we evaluated the glomerular transcriptome of microdissecte...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-50469 | biostudies-arrayexpress
TranscriptomicsExpression data from human with IgA nephropathy (IgAN)
This SuperSeries is composed of the following subset Series: GSE35487: Expression data from human with IgA nephropathy (IgAN) [HG-U133A] GSE35488: Expression data from human with IgA nephropathy (IgAN) [HG-U133A_ENTREZG_10] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35489 | biostudies-arrayexpress
TranscriptomicsExpression data from human with IgA nephropathy (IgAN) [HG-U133A]
Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether proteinuria is a marker of disease severity or h...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35487 | biostudies-arrayexpress
ProteomicsSerum proteomic analysis of circulating IgA1-containing immune complexes in patients with IgA nephropathy
IgA nephropathy (IgAN) is an autoimmune disease that involves galactose-deficient IgA1 (Gal-deficient IgA1) recognized by autoantibodies to form circulating immune complexes (IgA1-IC). Some of these complexes deposit in the glomeruli and induce kidney injury. Gal-deficient IgA1 alone is not sufficie...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD055562 | Pride
Proteomics Lc-ms Complement Orbitrap Raw Immune complexes Serum Iga nephropathy Glomerular disease 
TranscriptomicsExpression data from human with IgA nephropathy (IgAN) [HG-U133A_ENTREZG_10]
Proteinuria is the most important predictor of outcome in glomerulonephritis and experimental data suggest that the tubular cell response to proteinuria is an important determinant of progressive fibrosis in the kidney. However, it is unclear whether proteinuria is a marker of disease severity or h...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35488 | biostudies-arrayexpress
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