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TranscriptomicsLiver-derived IGF-I regulates mean life span in mice
In this study we used the cre-loxP recombinase system. All mice were genetically modified in as much as all mice had exon 4 of the IGF-I gene flanked by loxP sites. In the knockouts, Mx-Cre had also been introduced, which results in inactivation of the IGF-I gene specifically in the liver. RNA from ...
ORGANISM(S): Mus musculus 
2011-12-01 | E-MEXP-3026 | biostudies-arrayexpress
TranscriptomicsExpression data from MCF-7 cells stimulated by Estrogen or IGF-I
Although estrogen receptor (ER) and insulin-like growth factor (IGF) signaling are important for normal mammary development and breast cancer, cross-talk between these pathways, particularly at the level of gene transcription, remains poorly understood. We performed microarray analysis on MCF-7 bre...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-26834 | biostudies-arrayexpress
GenomicsExome sequencing of short SGA children with IGF I and insulin resistance
Exome sequencing of short SGA children with IGF-I and insulin resistance. Collaboration with Professor David Dunger, University of Cambridge. Funded by NIHR.
EGAS00001001086 | EGA
TranscriptomicsMicroRNA profiling by array of mouse skeletal muscle cells treated with TNF-alpha or IGF-I
Murine skeletal muscle cells pmi28 were cultured in growth medium (HamM-^Rs F10, supplemented with 20 % FCS, 2 mM L-glutamine, and 1 % Penicillin / Streptomycin). Myoblasts were cultured on laminin-1 coated dishes for an additional 24 h before switching a fraction of dishes to differentiation medium...
ORGANISM(S): Mus musculus 
2013-05-15 | E-MTAB-1114 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of uteri from gonadectomized C57BL/6 mice injected with 17-Estradiol (E2) to identify genes modulated by a physiological dose of E2 in uterus.
17ß-Estradiol (E2) is well known to be associated with uterine cancer, endometriosis, and leiomyomas. Although insulin-like growth factor I (IGF-I) has been identified as a mediator of the uterotrophic effect of E2 in several studies, this mechanism is still not well understood. In the present stud...
ORGANISM(S): Mus musculus 
2007-11-14 | E-GEOD-6219 | biostudies-arrayexpress
ProteomicsMouse myoblast fusion - Separating myoblast differentiation from muscle cell fusion using IGF-I and the p38 MAP kinase inhibitor SB202190
The p38 MAP kinases play critical roles in skeletal muscle biology, but the specific processes that they regulate remain poorly defined. Here we find that activity of p38α/β is important not only for early phases of myoblast differentiation, but also in later stages of myocyte fusion and myofibrill...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD002413 | Pride
Mouse Myoblast Differentiation Fusion 
Transcriptomics[E-MEXP-3786] IGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy
Transcription profiling by array of mouse male retinas to investigate IGF-I-induced chronic gliosis and retinal stress IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impai...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-46246 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human SK-N-AS neuroblastoma xenograft tumor treated with anti-human IGF-IR monoclonal antibody (h10H5) to study the anti-tumour function of the antibody
The insulin-like growth factor (IGF) system consists of two ligands (IGF-I and IGF-II), which both signal through type I IGF receptor (IGF-IR) to stimulate proliferation and inhibit apoptosis, with activity contributing to malignant growth of many types of human cancers. We have developed a humanize...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-11959 | biostudies-arrayexpress
TranscriptomicsGrowth Hormone Receptor and IGF-I Deficiency is Associated with Resistance to DNA Damage and Very Low Cancer and Diabetes Incidence in Humans
Growth Hormone Receptor Deficiency (GHRD) in mice causes life span extension and a major increase in the portion of animals that die without detectable pathologies including cancer and insulin resistance. During a 22-year monitoring of a cohort of 0-88 year old Ecuadorian GHRD subjects with severe I...
ORGANISM(S): Homo sapiens 
2010-12-25 | E-GEOD-21980 | biostudies-arrayexpress
TranscriptomicsIGF-I-induced chronic gliosis and retinal stress lead to neurodegeneration in an animal model of retinopathy
IGF-I exert multiple effects in different retinal cell populations in both physiological and pathological conditions. Transgenic mice overexpressing IGF-I in the retina showed impaired electroretinographic responses at 6-7 months of age that worsen with age. This retinal neuronal dysfunction was cor...
ORGANISM(S): Mus musculus 
2013-08-01 | E-MEXP-3786 | biostudies-arrayexpress
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