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ProteomicsPlasma and kidney proteome profiling combined with laser capture microdissection reveal large increases in immunoglobulins with age
One of the main hallmarks of aging is aging-associated inflammation, also known as inflammaging. In this study, by comparing young and old mice using LC-MS profiling, we show that immunoglobulins are the proteins that are most increased with age in plasma. This observation appears to have been previ...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-03 | PXD051031 | Pride
Aging Complement Kidney Laser capture microdissection Proteomics Immunoglobulins 
ProteomicsNovel antibody-peptide binding assay indicates presence of immunoglobulins against EGFR phospho-site S1166 in high-grade glioma.
The project’s aim was to develop and test the applicability of a method to determine the presence of serum immunoglobulins against specific autoantibodies. The method combined immunoglobulin G enrichment (using Melon Gel), molecular weight filtration, and targeted mass spectrometry and the feasibili...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-06-09 | PXD032844 | Pride
Glioblastoma Melon gel Peptide antigen Autoantibodies Immunoglobulin g 
ProteomicsAstrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However, their edification is different from the ones...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD040562 | Pride
Immunoglobulins Astrocytes 
ProteomicsEffects of human immunoglobulins on Cryptococcus neoformans morphology and proteome
Cryptococcus neoformans (Cn) is the main cause of fungal meningitis (CM) in people living with HIV. Perturbations in levels of normal immunoglobulin (Ig) levels are observed in these individuals, but their association with CM pathogenesis is unclear. Here, we investigated the physical and biological...
ORGANISM(S): Cryptococcus neoformans 
2026-01-26 | PXD072710 | Pride
Igm Cryptococcal capsule Cryptococcus neoformans Human immunoglobulins Igg Hiv Cryptococcal proteome. And iga Glucuronoxylomannan 
UnknownArtificial affinity proteins as ligands of immunoglobulins.
Not available
S-EPMC4384111 | biostudies-literature
ProteomicsMiddle-up analysis of polyclonal IgG-Fc
Middle-up strategy for the analysis of the fragment crystallizable (Fc) region of human plasma immunoglobulins G (IgGs). The use of hydrophilic interaction liquid chromatography (HILIC) and capillary electrophoresis (CE) coupled to mass spectrometry (MS) allowed to get a comprenhesive view of the N-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-08 | MSV000085388 | MassIVE
UnknownEffect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers.
Not available
S-EPMC8455986 | biostudies-literature
UnknownThe association of serum immunoglobulins with cognition and dementia: the Rotterdam Study.
Not available
S-EPMC9813113 | biostudies-literature
UnknownEndogenous monoclonal immunoglobulins analyzed using the EXENT® solution and LC-MS.
Not available
S-EPMC10891330 | biostudies-literature
UnknownIntravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study.
Not available
S-EPMC9260992 | biostudies-literature
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