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TranscriptomicsPcs1 and Mde4 are inner centromere proteins required to prevent merotelic kinetochore orientation
Chromosome segregation depends on proper attachment of sister kinetochores to microtubules. Merotelic kinetochore orientation is an error which occurs when a single kinetochore is attached to microtubules emanating form opposite poles. Mechanisms preventing or correcting the merotelic attachment mus...
ORGANISM(S): Schizosaccharomyces pombe 
2010-06-10 | E-GEOD-5257 | biostudies-arrayexpress
ProteomicsSpodoptera frugiperda kinetochore co-immunoprecipitations
Accurate chromosome segregation requires assembly of the multiprotein kinetochore complex at centromeres. In most eukaryotes, kinetochore assembly is primed by the histone H3 variant CenH3, which physically interacts with components of the inner kinetochore constitutive-centromere-associated-network...
ORGANISM(S): Spodoptera frugiperda Bombyx mori (Silk moth) 
2020-02-18 | PXD016092 | Pride
Bombix Kinetochore Frugiperda Spodoptera 
GenomicsOctameric nucleosomes are present within the inner kinetochore of human centromeres
Octameric nucleosomes are present within the inner kinetochore of human centromeres
PRJNA531000 | ENA
ProteomicsBridgin connects the outer kinetochore to centromeric chromatin
In this project, 3XFlag-tagged protein affinity purifications were performed to identify the protein-protein interactors using Cryptococcus neoformans cell lysate. After fractionation with SDS-PAGE, peptide samples for nanoLC-MS/MS were prepared by in-gel digestion. Raw data from Orbotrap Velos pr...
ORGANISM(S): Cryptococcus Neoformans 
2020-09-23 | PXD021072 | JPOST Repository
ProteomicsCENP-C-targeted PLK-1 regulates kinetochore function in C. elegans embryos
This project focused on the identification of phosphorylation sites on the C. elegans inner kinetochore protein CENP-C and the outer kinetochore complex MIS12. Phosphorylation was carried out in vitro using recombinant proteins. CENP-C was phosphorylated with Cdk1, PLK-1 or both; MIS12 complex compo...
ORGANISM(S): Caenorhabditis elegans 
2024-11-28 | PXD058379 | Pride
Plk-1 Inner kinetochore Cenp-c Mis12 complex. 
ProteomicsThe kinetoplastid outer kinetochore
In spite of their universal function, the composition of kinetochores differs greatly across eukaryotes. Trypanosomes and other organisms Kinetoplastida diverged very early during eukaryotic radiation from the line that includes animals and fungi, and build kinetochores with very little detectable h...
ORGANISM(S): Trypanosoma brucei 
2020-04-27 | PXD015100 | Pride
Kinetochore Chromosome segregation Kinetoplastida Trypanosoma Mitosis 
Genomics
Native yeast kinetochore structures identify an essential inner kinetochore interaction
PRJNA1427749 | ENA
ProteomicsArchitecture and Function of Holocentric CENP-A-Independent Inner Kinetochores
Kinetochores are essential macromolecular complexes anchoring chromosomes to the mitotic spindle, ensuring faithful cell division. Despite their critical role, the structural organization of kinetochores over large centromeric regions and across diverse species remains poorly understood. We present ...
ORGANISM(S): Spodoptera frugiperda 
2026-04-20 | PXD063391 | Pride
Kinetochore Insects Structure 
ProteomicsAssembly and phospho-regulatory mechanisms of the budding yeast outer kinetochore KMN complex
Crosslinking of KMN outer kinetochore complex. During mitosis and meiosis kinetochores mediate interactions between chromosomes and spindle microtubules. Kinetochores are multi-megadalton protein complexes essential for chromosome segregation in all eukaryotes, however recent structural, functional,...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-16 | PXD072662 | Pride
Kinetochore Cl-ms Crosslinking 
UnknownTrypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.
Not available
S-EPMC8023272 | biostudies-literature
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