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TranscriptomicsTranscription profiling of rat insulinoma-beta (INS-1E) cells exposed to the cytokines IL-1-beta and IFN-gamma for six different lengths of time and with or without the inducible NO synthase blocker NMA
Locally released cytokines contribute to beta cell dysfunction and apoptosis in Type 1 diabetes. In vitro exposure of insulin producing INS-1E cells to the cytokines interleukin (IL)-1beta + interferon (IFN) gamma leads to a significant increase in apoptosis. To characterize the genetic networks im...
ORGANISM(S): Rattus norvegicus 
2006-06-14 | E-CBIL-10 | biostudies-arrayexpress
TranscriptomicsExpression data from rat INS-1E cells
Cytokine-induced beta-cell apoptosis is a key event for the death of pancreatic beta cells in the development of type-1 diabetes. We identified BRD0476 as a novel suppressor of cytokine-induced beta-cell apoptosis. We used microarrays to look for gene set(s) that are regulated by BRD0476. Rat INS-1E...
ORGANISM(S): Rattus norvegicus 
2012-12-14 | E-GEOD-42897 | biostudies-arrayexpress
TranscriptomicsMiRNA profiling in Rattus norvegicus pancreatic cells: INS-1E cells during infection with Coxsackie B4 virus
This study aims at elucidating how Coxsackie B virus infection perturbs the host's miRNA regulatory pathways that may lead to different pathological events using the miRNA microarray approach. The rat pancreatic cell line - INS-1E, was infected with various preparations of Coxsackie B4 viruses was a...
ORGANISM(S): Rattus norvegicus 
2015-01-01 | E-GEOD-58691 | biostudies-arrayexpress
ProteomicsInteractome of Ca2+-bound secretagogin in INS-1E cells
By using His6-tagged recombinant human secretagogin in the presence of Ca2+ (100 µM), we precipitated putative interacting partners from INS-1E cells and identified their amino acid sequences by mass spectrometry. We detected canonical interacting proteins participating in vesicle-mediated transport...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-06-21 | PXD006544 | Pride
Ins-1e cell line His6-tagged recombinant secretagogin Pull down Protein-protein interactions 
GenomicsIntegrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells
Glucose is an important regulator of pancreatic β-cell function. In addition to the acute stimulation of insulin secretion, glucose stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β-cells. The glucose-sensin...
ORGANISM(S): Rattus norvegicus 
2016-09-06 | E-GEOD-81628 | biostudies-arrayexpress
ProteomicsTime course treatment with Palmitate and thapsigargin of insulinoma INS-1E cells
Time course treatment with 0.4 mM Palmitate and 200 nM thapsigargin of insulinoma INS-1E cells. Timepoints; 0, 4, 16 and 24h in biological duplicates within an iTRAQ 8 set for palmitate and thapsigargin, respectively.
ORGANISM(S): Rattus Rattus (black Rat) 
2020-08-18 | PXD020851 | JPOST Repository
GenomicsRNASeq data of rat Ins-1E insulinoma cells with and without internalised apoA-I
RNASeq of Ins-1E cells with internalised apoA-I (apoA-I positive) and Ins-1E cells without internalised apoA-I (apoA-I negative) from 3 independent experiments.
PRJEB50345 | ENA
ProteomicsTent5a Immunoprecipitation in pancreatic beta cells
Wild Type Tent5a or catalytically inactive Tent5a was over-expressed and immunoprecipitated from INS-1E cell lysates. Binding partners were identified using LC-MS.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-22 | PXD066929 | Pride
Lc-ms Immunoprecipitation Tent5a Pancreatic beta cells 
ProteomicsGlucose-dependent phosphorylation in insulin secreting cells
Shotgun proteomics including TiO2 enrichment of phosphorylated peptides followed by reversed-phase liquid chromatography tandem mass spectrometry (RP-LC MS/MS) on lysates from glucose-stimulated INS-1E cells was used to identify glucose regulated phosphorylated proteins and signal transduction pathw...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-02-25 | PXD011329 | Pride
Rat Ins-1e Phosphorylation Rp-lc ms/ms 
TranscriptomicsTranscription profiling of rat pancreatic INS-1E cells submitted to SILAC and different glucose levels
mRNAs of INS-1E cells submitted to SILAC and different glucose levels were compared
ORGANISM(S): Rattus norvegicus 
2009-12-31 | E-TABM-477 | biostudies-arrayexpress
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