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MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
TranscriptomicsThe long noncoding RNA expression profile of human intervertebral disc degeneration identified by microarray analysis
In addition to the well-known short noncoding RNAs as miRNAs, increasing evidence suggests that long noncoding RNAs (lncRNAs) act as key regulators in a wide aspect of biologic processes. Dysregulated expression of lncRNAs has been demonstrated being implicated in a variety of human diseases. Howeve...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-56081 | biostudies-arrayexpress
TranscriptomicsHuman notochordal cell transcriptome in the developing intervertebral disc
The adult nucleus pulposus originates from the embryonic notochord, but loss of notochordal cells with skeletal maturity in humans is believed to initiate intervertebral disc degeneration. Thus, defining the phenotype of human embryonic/fetal notochordal cells is essential for understanding their ro...
ORGANISM(S): Homo sapiens 
2018-08-29 | E-MTAB-6868 | biostudies-arrayexpress
TranscriptomicsDownregulation of miR-760 Causes Human Intervertebral Disc Degeneration by Targeting the MyD88/Nuclear Factor-Kappa B Signaling Pathway
Dysregulation of microRNAs (miRNAs) plays a critical role in the development of intervertebral disc degeneration (IDD). In this study, we present evidence from in vitro and in vivo research to elucidate the mechanism underlying the role of miR-760 in IDD. miRNA microarray and quantitative reverse tr...
ORGANISM(S): Homo sapiens 
2022-03-17 | E-MTAB-11554 | biostudies-arrayexpress
TranscriptomicsNoncoding RNAs in human intervertebral disc degeneration: an integrated microarray study
This SuperSeries is composed of the SubSeries listed below. Each of the SubSeries contained in this SuperSeries represents identical RNA samples used for hybridization to different array platforms. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-04-03 | E-GEOD-67567 | biostudies-arrayexpress
TranscriptomicsLS001A: Aging/Early Degeneration Of The Intervertebral Disc Involves Downregulation Of Canonical Wnt Signaling and Caveolin-1 expression
Objective: Aging and early degeneration of the intervertebral disc (IVD) involves the substition of notochordal cells (NCs) in the nucleus pulposus (NP) by chondrocyte-like cells (CLCs). This study investigated the gene expression profiles involved in this process using NP tissue from both non-chond...
ORGANISM(S): Canis lupus familiaris 
2013-01-31 | E-GEOD-35717 | biostudies-arrayexpress
ProteomicsIntegrated with Proteome-sequencing, bulk RNA-sequencing and Single cell RNA-sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration
We selected humann intervertebral disc samples to perform proteomics analysis. There were 1 case of grade I , 1 case of grade II, 3 cases of grade Ⅲ and 3 cases of grade Ⅳ according to Pfirrmann classfication. RNA seqencing analysis and single-cell RNA sequencing were integrated with proteomics data...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040593 | Pride
Intervertebral disc degeneration Proteome-sequencing 
TranscriptomicsTranscription profiling of bovine nucleus pulposus, carticular cartilage and annulus fibrosus cells to further determine expression in normal and degenerate human intervertebral disc
The aim of this transcription profiling study was to identify novel genes that could be used to distinguish bovine Nucleus pulposus (NP) cells from articular cartilage (AC) and annulus fibrosus (AF) cells and to further determine their expression in normal and degenerate human intervertebral disc (I...
ORGANISM(S): Bos taurus 
2010-03-05 | E-MEXP-2291 | biostudies-arrayexpress
ProteomicsMass spectrometry analysis of degenerated human intervertebral disc tissues
Mass spectrometry analysis of degenerated human intervertebral disc tissues obtained during elective surgery to treat low back pain
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD056620 | Pride
Human Degeneration Mass spectometry Intervertebral disc Dda 
ProteomicsMatrisome remodelling during Intervertebral Disc development and ageing
Intervertebral disc (IVD) degeneration is often the cause of low back pain. Degeneration occurs with age and is accompanied by extracellular matrix (ECM) depletion, culminating in nucleus pulpous (NP) extrusion and IVD destruction. The changes that occur in the disc with age have been under investi...
ORGANISM(S): Bos taurus (Bovine) 
2017-09-25 | PXD005616 | Pride
Foetus Extracellular matrix Development Intervertebral disc Ageing 
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