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MetabolomicsUntargeted metabolomics profiling of intestinal epithelium-specific PCK1 knockout mice and littermate controls

Metabolic dysregulation may serve as a pivotal driver of inflammatory bowel disease, with the crosstalk between metabolism and the immune system emerging as a critical research focus. Ulcerative colitis patients exhibit enhanced glycolysis but suppressed ...

2026-06-24 | MTBLS12440 | MetaboLights
TranscriptomicsRNA-seq of mouse small intestinal epithelium at different development stages (E18.5, P7, P21)
To assess the role of genes in development in mouse small intestinal epithelium, we isolated intestinal epithelium tissue from wild type mice at E18.5, P7 and P21. RNA was directly isolated used for RNA seq and were able to investigate gene expression at different development stages
ORGANISM(S): Mus musculus 
2020-11-16 | E-MTAB-8713 | biostudies-arrayexpress
GenomicsH3K4me1 ChIP-seq of mouse small intestinal epithelium at different development stages (E18.5, P7, P21)
To assess the role of H3K4me1 in development in mouse small intestinal epithelium, we isolated intestinal epithelium tissue from wild type mice at E18.5, P7 and P21. This tissue was digested to single cells, sorted, fixed, isolated chromatin, and performed ChIP using an H3K4me1 antibody as described...
ORGANISM(S): Mus musculus 
2020-11-16 | E-MTAB-8710 | biostudies-arrayexpress
TranscriptomicsExpression data from heterotopically grafted mouse small intestinal epithelium and the normal colonic epithelium
Epithelia of small and large intestines differ in their structures and functions. Such heterogeneity between these two epithelial tissues might be controlled by both epithelium-intrinsic and -extrinsic programs. By employing the cell transplantation technique developed in our laboratory, we investig...
ORGANISM(S): Mus musculus 
2014-08-15 | E-GEOD-59410 | biostudies-arrayexpress
TranscriptomicsIMPACT OF INTERLEUKIN 10 DEFICIENCY ON INTESTINAL EPITHELIUM RESPONSES TO INFLAMMATORY SIGNALS
Interleukin-10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system have been extensively studied, its intrinsic role in intestinal epithelial cells is poorly understood. In t...
ORGANISM(S): Mus musculus 
2021-12-30 | E-MTAB-10217 | biostudies-arrayexpress
GenomicsChIP-sequencing of the H3K4me1/2 in crypts from mice intestinal epithelium with intestinal epithelium specific LSD1 knock out compared to wild type
To study the epigenetic regulation of intestinal epithelium we focus on the role of chromatin modulators. Lysine-specific histone demethylase 1a (KDM1A, LSD1) is one of the enzymes that can erase the H3K4me1/2 mark. To assess the role of LSD1 in intestinal epithelium we studied wild type (WT) (Villi...
ORGANISM(S): Mus musculus 
2020-11-16 | E-MTAB-7871 | biostudies-arrayexpress
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
TranscriptomicsRNA-seq of small intestinal organoids treated with an inhibitor for the epigenetic modifier LSD1
To assess the role of LSD1 in mice small intestinal epithelium, small intestinal organoids were treated with an inhibitor for LSD1 (GSK-LSD1) and compared to untreated organoids. Similar to intestinal epithelium from mice with an intestinal epithelium specific LSD1-KO, paneth cells dissappear upon G...
ORGANISM(S): Mus musculus 
2020-11-16 | E-MTAB-9077 | biostudies-arrayexpress
TranscriptomicsATAC-sequencing mice small intestinal epithelium with intestinal epithelium specific LSD1 knock out compared to wild type
To study the epigenetic regulation of intestinal epithelium we focus on the role of chromatin modulators. Lysine-specific histone demethylase 1a (KDM1A, LSD1) is one of the enzymes that can erase the H3K4me1/2 mark. To assess the role of LSD1 in intestinal epithelium we studied wild type (WT) (Villi...
ORGANISM(S): Mus musculus 
2021-03-23 | E-MTAB-8718 | biostudies-arrayexpress
TranscriptomicsRNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis
The intestinal epithelium is our first line of defense against infections of the gut and the plasticity in cellular differentiation of the intestinal epithelium is an important part of this response. Here we sequenced the small intestinal epithelium from mice infected with Nippostrongylus brasiliens...
ORGANISM(S): Mus musculus 
2022-05-08 | E-MTAB-9183 | biostudies-arrayexpress
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