Sort   by:  
 Page size 
TranscriptomicsAltered Expression of Intraflagellar Transport Genes is Associated with Short Cilia in Smoking and COPD
Study Smoking and COPD are associated with decreased mucociliary clearance and healthy smokers have shorter cilia in the large airway than nonsmokers. Intraflagellar transport (IFT) is the process by which cilia are produced and maintained. We assessed expression of IFT-related genes in smokers and ...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-43939 | biostudies-arrayexpress
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049195 | JPOST Repository
ProteomicsExtensive structural rearrangement of intraflagellar transport trains underpins bidirectional cargo transport (Proteomics
Bidirectional transport in cilia is carried out by polymers of the IFTA and IFTB protein complexes, referred to as anterograde and retrograde IFT “trains”. Anterograde trains deliver cargoes from the cell to the ciliary tip, then remodel into retrograde trains for cargo export. We set out to underst...
ORGANISM(S): Chlamydomonas Reinhardtii 
2024-08-21 | PXD049260 | JPOST Repository
TranscriptomicsTranscriptional profiling of C. elegans DAF-19 uncovers a ciliary base-associated protein and a CDK/CCRK/LF2p-related kinase required for intraflagellar transport.
Cilia are ubiquitous cell surface projections that modulate various sensory- and motility based processes and are implicated in a growing number of multi-organ genetic disorders termed ciliopathies. As new components required for cilium biogenesis and function remain unidentified, we sought to furth...
ORGANISM(S): Caenorhabditis elegans 
2011-07-25 | E-GEOD-25633 | biostudies-arrayexpress
ProteomicsBiochemically validated structural model of the 15-subunit intraflagellar transport complex IFT-B
Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and sensory reception. Cilium formation requires intraflagellar transport of structural and signaling components and involves 22 different proteins organized into intraflagellar transport (IFT) complexes IFT-A and ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-02 | PXD037049 | Pride
Protein structure Intraflagellar transport Cross-linking Proteomics Cilia 
GenomicsOsteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity II
Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity II
PRJNA739660 | ENA
GenomicsOsteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity I
Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity I
PRJNA739643 | ENA
ProteomicsCEP19-RABL2 GTPase complex in ciliary transport
The mechanisms of how highly conserved intraflagellar transport (IFT) protein complexes direct ciliary entry remain unknown. Exploring human ciliopathy genes, including monogenic obesity syndrome genes, has been a rich source of critical ciliary mechanisms. Using AP-MS purification of interactors of...
ORGANISM(S): Homo sapiens (Human) 
2017-06-21 | PXD006757 | Pride
Metabolic syndrome Gtpase Cep19-rabl2b complex Microtubules Bardet-biedl syndrome Proteomics Genetics" Obesity Ciliopathy Human genetics Centrosome Intraflagellar transport Centriole Cilia 
GenomicsOsteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity
Osteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity
PRJNA739651 | ENA
TranscriptomicsOsteoblast-derived intraflagellar transport 140 suppresses insulin sensitivity I
Hyperglycemia-induced damage to bone formations and function has been recognized.However, as the largest connective tissue organ, whether bone and osteocytes in turn regulate blood sugar and insulin sensitivity has not been addressed. Here we identified a novel protein termed intraflagellar transpor...
ORGANISM(S): Mus musculus 
2021-06-24 | GSE178548 | GEO
Sort   by:  
 Page size