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GenomicsEngineering intrinsically disordered regions (IDRs) for guiding genome navigation
Engineering intrinsically disordered regions (IDRs) for guiding genome navigation
PRJNA1230175 | ENA
ProteomicsIntrinsically Disordered Regions in Chromodomain Helicase DNA-binding (CHD) Proteins Shape Distinct Protein Interaction Networks
Metazoans employ chromodomain helicase DNA-binding (CHD) enzymes to reposition nucleosomal DNA for transcription and replication. The CHD family consists of nine distinct members (CHD1-9) that possess highly conserved chromo and ATPase domains. These domains are flanked by poorly characterised N- an...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD055009 | Pride
Dna helicase Chromatin remodelers Transcription Intrinsically disordered regions Aggregation prone regions Protein-protein interactions 
UnknownForkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.
Not available
S-EPMC5314938 | biostudies-literature
ProteomicsBiotin proximity tagging favors unfolded proteins and enables the study of intrinsically disordered regions
Intrinsically Disordered Regions (IDRs) are enriched in disease-linked proteins known to have multiple post-translational modifications, but there is limited in vivo information about how locally unfolded protein regions contribute to biological functions. We reasoned that IDRs should be more access...
ORGANISM(S): Escherichia coli 
2020-01-29 | PXD016422 | Pride
Lc-sps-ms3 E. coli H. sapiens Idr Biotin 
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - PRM dataset-
Mutations in intrinsically disordered regions (IDRs) of proteins are associated with a wide spectrum of diseases. Since IDRs lack a fixed three-dimensional structure, the molecular mechanism by which such mutations cause disease is often unknown. Here, we employ a peptide-based proteomic screen to i...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010005 | Pride
Glut1 Disordered regions Prm Dileucin 
UnknownArchaic chaos: intrinsically disordered proteins in Archaea.
Not available
S-EPMC2880407 | biostudies-literature
ProteomicsMutations in disordered regions cause disease by creating dileucine motifs - peptide-protein interaction screen
Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of proteins. Since these mutations do not affect protein structure, the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a peptide-based proteomic screen to investigate the impact of mutati...
ORGANISM(S): Homo sapiens (Human) 
2018-09-13 | PXD010027 | Pride
Peptide array Ppi Protein-protein interaction Disordered regions 
GenomicsIntrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria
PRJNA1065311 | ENA
ProteomicsCell-type-specific functionality encoded within the intrinsically disordered regions of OCT4.
The cell-type-specific function of transcription factors (TFs) is crucial for determining several cellular identities. It is unclear how a single TF can function specifically in different cell types. Here, we define the molecular features that enable OCT4 to reprogram somatic cells into pluripotent ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD067538 | Pride
Oct4 Intrinsically disordered regions Embryonic stem (es) cells Transcription factors Slipers 
GenomicsIntrinsically disordered regions of transcription factor encode multiple functions using interwoven sequence grammars (ChEC-seq)
Intrinsically disordered regions of transcription factor encode multiple functions using interwoven sequence grammars (ChEC-seq)
PRJNA1001336 | ENA
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