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ProteomicsThiol reactive tandem mass tags for quantitative top-down proteomics
Here, we describe the development of a labeling strategy for TDP targeting thiol groups of cysteine residues with iodoTMTsixplex. While this method inherently excludes the quantification of cysteine-free proteoforms, it provides the opportunity of sixplexing and the implementation of multidimensiona...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2021-08-06 | PXD026310 | Pride
Isobaric labeling Gelfree High ph fractionation Yeast Iodotmtsixplex Quantitative top-down proteomics Saccharomyces cerevisae Escherichia coli 
ProteomicsArabidopsis thaliana PTM dynamics during dark-light transition
Two proteomics DDA experiments investigating dynamics of post-translational modifications in Arabidopsis thaliana whole leaf rosettes at multiple harvest times around dark to light transition. One experiment regarding acetylation (K) and phosphorylation (STY) after serial enrichment of dimethyl labe...
ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress) 
2023-07-21 | PXD041832 | JPOST Repository
ProteomicsMemo1 promotes FGF23-driven signaling by oxidative modulation of small Rho-GTPases and protein tyrosine phosphatase activity
Memo is a copper-dependent redox enzyme modulating receptor tyrosine kinase signaling by unknown mechanisms (Meira et al., Nat Cell Biol 2004; MacDonald et al., Science Signal 2014). Memo1 deletion causes a phenotype partially resembling Klotho and Fgf23-deficient mice (Haenzi et al., FASEB J 2014; ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD022382 | Pride
Arhgdia Rhogdi1 Redox signaling Memo1 Cysteine oxidation 
ProteomicsIdentification of heat induced proteins in young tomato flower buds
Tomato flowering and fruit set require an optimal temperature of 25/22 ± 2˚C (day/night). When the air temperature reaches to above the optimal range (higher than 30/26˚C; day/night), only a small number of flower buds would develop into mature flowers and produce a reduced number of pollen. This p...
ORGANISM(S): Solanum lycopersicum x Solanum tuberosum 
2022-03-03 | PXD012160 | Pride
Iodotmt  tomato flower 
ProteomicsRedox-proteomic analysis of pancreatic β-cells upon glucose stimulation
Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes, maintaining homeostasis, and ensuring proper function. This is particularly critical in pancreatic β-cells, which are highly metabolically active...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2024-09-30 | PXD052765 | Pride
Iodotmt Redox proteomics 
ProteomicsGlobal proteome-wide analysis of cysteine S-nitrosylation in Toxoplasma gondii
Toxoplasma gondii transmitted via various route and rapidly duplicated during the acute infection, which caused the important zoonosis regarding to medicine and veterinary, toxoplasmosis. T. gondii possessed innate capability of producing nitric oxide (NO) and nitric oxide derivatives and S-nitrosyl...
ORGANISM(S): Toxoplasma gondii 
2024-01-26 | PXD046083 | Pride
Toxoplasma gondii  post-translational modifications  cysteine s-nitrosylation  s-nitrosylated pro-teome 
ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, redox proteomic analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028780 | Pride
Peroxiredoxin 6 Cellular senescence Silac-iodotmt Ionizing radiation Redox proteomics 
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