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MetabolomicsHigh-confidence untargeted lipidomics of mammalian serum using LC-TIMS-PASEF

This study aimed to establish and validate a robust untargeted lipidomics workflow for the analysis of human serum using reversed-phase liquid chromatography coupled to trapped ion mobility spectrometry time-of-flight mass spectrometry (RP-LC-TIMS-TOF MS). Commercial pooled human serum was used a...

2026-05-26 | MTBLS14002 | MetaboLights
MetabolomicsNutrient environment drives strain-specific remodelling of Escherichia coli lipidomes
Background/Objectives: Escherichia coli causes more than 2.8 million infections annually and is widely used as a model organism. Despite its importance, strain-level and handling differences in E. coli lipidomes remain poorly defined. Lipid composition can reveal membrane organization, metabolic sta...
2026-09-23 | MTBLS14565 | MetaboLights
ProteomicsNew Insights into the impact of Human Papillomavirus on Oral Cancer in Young Patients: Proteomic Approach Reveals a Novel Role for S100A8
Human Papillomavirus (HPV) infection has been recently linked to a subset of cancers affecting the oral cavity. However, the molecular mechanisms underlying HPV-driven oral squamous cell carcinoma (OSCC) onset and/ progression are poorly understood. Methods: We perform a MS-based proteomic profiling...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041856 | Pride
New insights into the impact of human papillomavirus on oral cancer in young patients: proteomic approach reveals a novel role for s100a8 
UnknownInfluence of particle size on metal release from a cobalt- and nickel-containing alloy powder in an in vitro surrogate gastric fluid.
Not available
S-EPMC12367862 | biostudies-literature
TranscriptomicsTranscription profiling of mouse heart from E12.5 wildtype- and Sp3 animals
Mice lacking the zinc finger transcription factor Specificity protein 3 (Sp3) die prenatally in the C57Bl/6 background. To elucidate the cause of mortality we analyzed the potential role of Sp3 in embryonic heart development. Sp3 null hearts display defective looping at E10.5, and at E14.5 the Sp3 n...
ORGANISM(S): Mus musculus 
2008-06-17 | E-GEOD-9124 | biostudies-arrayexpress
TranscriptomicsSuppression of breast tumor growth and metastasis by an engineered transcription factor
Abstract Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of metastatic disease by epigenetic mechanisms. Reprogramming of Maspin epigenetic silencing offers a therapeutic...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-27842 | biostudies-arrayexpress
TranscriptomicsGeneration of tumor initiating cells by exogenous delivery of OCT4 transcription factor
Introduction: Tumor initiating cells (TICs) are being extensively studied for their role in tumor etiology, maintenance and resistance to treatment. The isolation of TICs has been limited by the scarcity of this population in the tissue of origin and because the molecular signatures that characteriz...
ORGANISM(S): Homo sapiens 
2011-08-16 | E-GEOD-26539 | biostudies-arrayexpress
ProteomicsFFPE oral cancer - Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer
Laser Microdissection (LMD) associated to LC-MS/MS were used to analyze the proteome of neoplastic islands and stroma tumor of Formalin-Fixed and Paraffin Embedded (FFPE) OSCC tissues to identify proteins of prognostic value. Label-free protein quantification and statistical analysis revealed neopla...
ORGANISM(S): Homo sapiens (Human) 
2018-09-10 | PXD007232 | Pride
Lc-ms/ms Ffpe Oscc 
TranscriptomicsThe transcription factor GATA3 controls cell fate and maintenance of type 2 innate lymphoid cells
The microarray was designed in order to detect transcriptional similarities/differences between innate immune cells (ILCs) in the lamina propria (N;L;R) and a putative precursor cell type detected in the bone marrow (P) of untreated mice in steady-state.
ORGANISM(S): Mus musculus 
2012-10-18 | E-MEXP-3743 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of Xylella fastidiosa 9a5c (pathogenic, reference strain) and J1a12 (non-pathogenic)
Comparison of genomic DNA from two strains of Xylella fastidiosa: 9a5c (pathogenic, reference strain) and J1a12 (non-pathogenic).
ORGANISM(S): Xylella fastidiosa 
2004-04-01 | E-MEXP-22 | biostudies-arrayexpress
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