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MetabolomicsMicroglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
ProteomicsSpecies-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction
Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS)to glycolysis, or alterations in other metabolic pathways. However, most of the experimental findings have been acquired in m...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-09-02 | PXD043836 | Pride
Human Lps treatment Mouse Microglia 
ProteomicsSecretome profiling of iPSC-derived microglia from β-propeller protein-associated neurodegeneration patients
Microglia are the brain’s resident immune cells, essential for homeostasis and implicated in common neurodegenerative diseases like Alzheimer’s and Parkinson’s disease (PD), where their early activation and sustained inflammatory mediator release precede neuronal loss. By contrast, their contributio...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD071930 | Pride
Bpan Microglia Hispecs Secretome 
ProteomicsTMT proteomic analysis of PFN1 iPSC-microglia
To compare the proteome between PFN1 mutant and PFN1 WT iPSC-microglia under baseline conditions
ORGANISM(S): Homo sapiens (Human) 
2024-02-18 | PXD038943 | Pride
Human Als Microglia Profilin 1 
GenomicsRNAseq Iron-Treated iPSC-derived Microglia
Iron accumulation in microglia has been observed in Alzheimer’s disease and other neurodegenerative disorders and is thought to contribute to disease progression through various mechanisms including neuroinflammation. To study the interaction between iron accumulation and inflammation, we treat...
EGAS00001006112 | EGA
GenomicsBulk RNA sequencing of human iPSC-derived microglia
Bulk RNA sequencing of human iPSC-derived microglia
PRJNA1182687 | ENA
GenomicsRNA-seq of isogenic NPC1 mutant iPSC-derived microglia like cells
RNA-seq of isogenic NPC1 mutant iPSC-derived microglia like cells
PRJNA763793 | ENA
ProteomicsLabelfree proteomics in Extracellular vesicles from human microglia cells
Label-free proteomics is used to study the role of the intracellular sorting receptor SORLA in the formation of functional exosomes by iPSC-derived human microglia.
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD064297 | Pride
Lc-msms Extracellular vesicles Sorla 
GenomicsBulk RNAseq in control and LACTB KO iPSC-derived microglia
Bulk RNAseq in control and LACTB KO iPSC-derived microglia
PRJNA1432735 | ENA
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