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ProteomicsIsotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
In the presented datasets, we use newly developed isotopically labeled desthiobiotin azide (isoDTB) tags to residue-specifically quantify cysteines in a variety of bacterial strains and a human cell line with consistently high coverage. We e.g. quantify 59% of all cysteines in essential proteins in ...
ORGANISM(S): Staphylococcus aureus 
2019-12-02 | PXD015457 | Pride
Covalent inhibitors Antibiotics Protein modifications Isotopic labeling Proteomics 
UnknownIsotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome.
Not available
S-EPMC7027453 | biostudies-literature
UnknownIsotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling.
Not available
S-EPMC5841085 | biostudies-literature
UnknownMulticolor live-cell chemical imaging by isotopically edited alkyne vibrational palette.
Not available
S-EPMC4063185 | biostudies-literature
UnknownOverexpression of recombinant proteins containing non-canonical amino acids in Vibrio natriegens: p-azido-L-phenylalanine as coupling site for <sup>19</sup>F-tags.
Not available
S-EPMC9217835 | biostudies-literature
ProteomicsAc-IP tag enables multiplexed proteome quantification in data-independent acquisition mode
We propose the isotopically labeled Ac-IP (acetyl-isoleucine-proline) tag for multiplexed quantification of peptides at the MS1 level in the data-independent acquisition (DIA) mode. Differentially labeled peptides have distinct precursor ions carrying the quantitative information but identical MS2 s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-06-07 | PXD022606 | Pride
Quantitative proteomics Isotope labeling Data-independent acquisition 
UnknownFunctionalizing tandem mass tags for streamlining click-based quantitative chemoproteomics.
Not available
S-EPMC11006884 | biostudies-literature
UnknownSolid-Phase Compatible Silane-Based Cleavable Linker Enables Custom Isobaric Quantitative Chemoproteomics.
Not available
S-EPMC11895830 | biostudies-literature
ProteomicsA tailored phosphoaspartate probe unravels CprR as a response regulator in Pseudomonas aeruginosa interkingdom signaling
Pseudomonas aeruginosa is a difficult-to-treat Gram-negative bacterial pathogen causing life-threatening infections. Adaptive resistance (AR) to cationic peptide antibiotics such as polymyxin B impairs the therapeutic success. This self-protection is mediated by two component systems (TCS) consistin...
ORGANISM(S): Pseudomonas aeruginosa PAO1 Escherichia coli Bacillus subtilis 
2021-02-16 | PXD022426 | Pride
Response regulator P. aeruginosa Adaptive resistance Antimicrobial peptide Phosphorylation Activity-based protein profiling Parallel reaction monitoring Isotopically labeled tags B. subtilis 
ProteomicsA solid-phase compatible silane-based cleavable linker enables custom isobaric quantitative chemoproteomics
Only ~4% of the human proteome has been drugged by FDA approved molecules. Consequently, closing this druggability gap is a central focus of mass spectrometry chemoproteomics screening platforms. Despite increasingly widespread adoption, established chemoproteomic platforms fall short of achieving c...
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD040737 | Pride
Cleavable Ms2 Tmt Isobaric Sclip Dadps Lc-msms Solid-phase 
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