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no omics definedTranscription profiling of thrombin stimulated human microvascular endothelial cell line-1 (HMEC1) over time and vs untreated cells
Thrombin exerts pleiotropic effects on the endothelium. Nevertheless, little is known about its capacity to generate endothelial microparticles, a hallmark of endothelial activation. To gain insight into the mechanisms involved in microparticles release, the human microvascular endothelial cell line...
ORGANISM(S): Homo sapiens 
2006-01-20 | E-MEXP-477 | biostudies-arrayexpress
UnknownPlasma-derived C1 esterase inhibitor pharmacokinetics and safety in patients with hereditary angioedema.
Not available
S-EPMC10684372 | biostudies-literature
UnknownAdd-on PD-1 inhibitor with Peg-IFNα therapy favors functional cure of chronic hepatitis B patients.
Not available
S-EPMC12916265 | biostudies-literature
ProteomicsTargeting Ubiquitin-specific proteases (USP14) Reduces Metastatic Potential and Metabolic Activity in Cervical Cancer by Modulating MCT-4
Cervical cancer is the most common cancer among women worldwide, predominantly caused by human papillomavirus (HPV) subtypes, particularly HPV 16 and 18. Although it is largely preventable through vaccination and early detection, cervical cancer remains a significant health issue, particularly in lo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD067901 | Pride
Chemoresistance Tcga Iu-1 inhibitor Lactate efflux Ubiquitin-specific proteases Mct-4 Molecular docking Metabolic reprogramming Usp14 Deubiquitinating enzymes (dubs) Proteomics Metastasis Cervical cancer 
UnknownSUN-086 Pilot Study Using Aromatase Inhibitor in Puberty of Boys With Partial Androgen Insensitivity: Report of Three Cases
Not available
S-EPMC7208264 | biostudies-literature
UnknownPreclinical Profile and Clinical Efficacy of a Novel Hepatitis C Virus NS5A Inhibitor, EDP-239.
Not available
S-EPMC5038307 | biostudies-literature
TranscriptomicsIn vitro responses of fibroblasts from patients with TBK1 deficiency after TLR3 dependent and independent stimuli
We report here two unrelated HSE patients carrying different heterozygous mutations (D50A and G159A) in TBK1, the gene encoding TANK-binding kinase 1, a kinase at the crossroads of multiple IFN-inducing signaling pathways. Both mutant TBK1 alleles are loss-of-function, but through different mechanis...
ORGANISM(S): Homo sapiens 
2012-07-29 | E-GEOD-38652 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiles in Oct4-knockdown and Ccna2-knockdown mouse embryos.
Gene regulation at the maternal-embryonic transition in the pre-implantation mouse embryo is not well understood. We knock down Ccna2 to establish proof-of-concept that antisense morpholino oligonucleotides can be used to target specific genes. We applied this strategy to study Oct4 and discovered...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-13981 | biostudies-arrayexpress
ProteomicsSILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor-treated and resistant tumor cells
The immunopeptidome is constantly monitored by T cells to detect foreign or aberrant HLA peptides. It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determine how cha...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054097 | Pride
Kinase inhibitor resistance Immunopeptidomics Cancer Mass-spectrometry Cryptic peptides Mapk signaling Melanoma Lc-ms/ms 
UnknownSubcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study.
Not available
S-EPMC6714075 | biostudies-literature
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