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ProteomicsIWS1 Stimulates Pol II Transcription Elongation In Vivo (revision data)
The protein IWS1 (Interacts with SPT6 1) has been implicated in various transcription-associated processes, but whether it has a direct role in RNA polymerase (Pol) II transcription remains unclear. Here, we establish a rapid depletion system for IWS1 in human cells, and use it to elucidate its func...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD066658 | Pride
Proteomis Iws1 Chromatin 
ProteomicsIWS1 Stimulates Pol II Transcription Elongation In Vivo
The protein IWS1 (Interacts with SPT6 1) has been implicated in various transcription-associated processes, but whether it has a direct role in RNA polymerase (Pol) II transcription remains unclear. Here, we establish a rapid depletion system for IWS1 in human cells, and use it to elucidate its func...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD056248 | Pride
Transcriptional elongation Transcription Rna polymerase ii Histone modifications H3k36me3 Setd2 Iws1 
ProteomicsIWS1 stimulates transcription elongation
Transcription elongation requires the coordination of many factors, but the molecular role of these factors are not fully understood. We used cryo-electron microscopy and in vitro RNA extension assays to show that the histone chaperone IWS1 stimulates transcription using a series of short motifs in ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD076498 | Pride
Human Lc-ms/ms 
GenomicsIWS1 Stimulates Pol II Transcription Elongation In Vivo [ChIP-Seq]
IWS1 Stimulates Pol II Transcription Elongation In Vivo [ChIP-Seq]
PRJNA1157817 | ENA
GenomicsIWS1 Stimulates Pol II Transcription Elongation In Vivo [RNA-Seq]
IWS1 Stimulates Pol II Transcription Elongation In Vivo [RNA-Seq]
PRJNA1157818 | ENA
GenomicsIWS1 Stimulates Pol II Transcription Elongation In Vivo [mNET-seq]
IWS1 Stimulates Pol II Transcription Elongation In Vivo [mNET-seq]
PRJNA1157823 | ENA
GenomicsInfluence of IWS1 TND-interacting motifs (TIMs) on transcription elongation [PRO-seq]
Influence of IWS1 TND-interacting motifs (TIMs) on transcription elongation [PRO-seq]
PRJNA745686 | ENA
GenomicsInfluence of IWS1 TND-interacting motifs (TIMs) on gene expression patterns [RNA-seq]
Influence of IWS1 TND-interacting motifs (TIMs) on gene expression patterns [RNA-seq]
PRJNA745577 | ENA
GenomicsInfluence of IWS1 TND-interacting motifs (TIMs) on chromatin localization patterns [ChIP-seq]
Influence of IWS1 TND-interacting motifs (TIMs) on chromatin localization patterns [ChIP-seq]
PRJNA745575 | ENA
UnknownIWS1 positions downstream DNA to globally stimulate Pol II elongation.
Not available
S-EPMC12368070 | biostudies-literature
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