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UnknownReference values for handgrip strength and their association with intrinsic capacity domains among older adults.
Not available
S-EPMC6463468 | biostudies-literature
UnknownTrends in Multicomponent Training Research in the Aged Population: A Bibliometric Analysis.
Not available
S-EPMC11311504 | biostudies-literature
ProteomicsProteomic analysis of serum EVs derived from PSC, CCA and PSC-CCA patients
Cholangiocarcinomas (CCAs) are heterogeneous biliary cancers with dismal prognosis. Their etiologies remain mostly unclear, although primary sclerosing cholangitis (PSC) is a well-known risk factor. There is an urgent need of accurate non-invasive biomarkers for early CCA diagnosis and to predict pa...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD026197 | Pride
Psc Liver Evs Cca 
ProteomicsPevonedistat inhibits aberrant protein NEDDylation in Polycystic Liver Diseases.
Background: Polycystic liver diseases (PLD) are genetic disorders characterized by progressive growth of numerous liver cysts, causing significant morbidity. Previous studies revealed genes affecting protein biogenesis and more recently, protein SUMOylation, a posttranslational modification (PTM), h...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD022571 | Pride
Hepatic cystogenesis  mln4924  pevonedistat  neddylation  therapy  nae1. 
ProteomicsTargeting UBC9-mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models
Background & Aims: polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or transport. Post-translational modifications (PTMs) are implicated in protein st...
ORGANISM(S): Homo sapiens (Human) 
2020-09-29 | PXD021140 | Pride
Hepatic cystogenesis Post-translational modifications Sumoylation S-adenosylmethionine (same) Therapy. 
ProteomicsTargeting UBC9-mediated Protein Hyper-SUMOylation in Cystic Cholangiocytes Halts Polycystic Liver Disease in Experimental Models
Background & Aims: polycystic liver diseases (PLDs) are genetic disorders characterized by progressive development of multiple fluid-filled biliary cysts. Most PLD-causative genes participate in protein biogenesis and/or transport. Post-translational modifications (PTMs) are implicated in protein st...
ORGANISM(S): Homo sapiens (Human) 
2020-09-29 | PXD021139 | Pride
Hepatic cystogenesis Post-translational modifications Sumoylation S-adenosylmethionine (same) Therapy. 
ProteomicsNovel chemotherapy selectively induces double-strand DNA breaks and death in naïve and Cisplatin-resistant cholangiocarcinoma tumours - total proteomics and phosphoproteomics
Background & Aims: Patients with cholangiocarcinoma (CCA) have poor prognosis. Current first-line chemotherapy, including Cisplatin and Gemcitabine, provides limited survival benefits due to the development of chemoresistance. Cisplatin induces single-strand DNA breaks, activating DNA repair mechani...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD061935 | Pride
Cancer cells  cancer-associated fibroblasts  chemoresistance  novel therapy  dna crosslinks  chromatin remodeling Phosphoproteomics Label free 
ProteomicsLiquid biopsy protein biomarkers of cholangiocarcinoma risk, early diagnosis and survival mirroring tumor cells - timsTOF (2/2)
Background & Aims: Cholangiocarcinomas (CCAs), heterogeneous biliary tumors with dismal prognosis, lack accurate early-diagnostic methods, especially important for individuals at high-risk (i.e., primary sclerosing cholangitis (PSC)). Here, we searched for protein biomarkers in serum extracellular v...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037007 | Pride
Cca Serum Extracellular vesicles Timstof 
ProteomicsLiquid biopsy protein biomarkers of cholangiocarcinoma risk, early diagnosis and survival mirroring tumor cells - timsTOF (1/2)
Background & Aims: Cholangiocarcinomas (CCAs), heterogeneous biliary tumors with dismal prognosis, lack accurate early-diagnostic methods, especially important for individuals at high-risk (i.e., primary sclerosing cholangitis (PSC)). Here, we searched for protein biomarkers in serum extracellular v...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036943 | Pride
Cholangiocarcinoma  extracellular vesicles  primary sclerosing cholangitis  biomarkers  liquid biopsy  single-cell rna-sequencing  mass spectrometry 
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