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ProteomicsRAD54L2 mediates a novel mechanism to counter TOP2-DNA adducts
The catalytic cycle of topoisomerase 2 (TOP2) enzymes proceeds via a transient DNA double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in which the TOP2 protein is covalently bound to DNA. Anti-cancer agents such as etoposide operate by stabilising TOP2ccs, ultimately g...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046611 | Pride
Cancer Top2-dna adducts Etoposide Rad54l2 
ProteomicsATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
Mutations in the ATM tumor suppressor gene confer cellular hypersensitivity to various DNA-damaging chemotherapeutic agents. To explore genetic resistance mechanisms towards such drugs, we performed genome-wide CRISPR-Cas9 loss-of-function screens in cells treated with the DNA topoisomerase I poison...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD011108 | Pride
Atm Dna damage response 
ProteomicsShieldin complex promotes DNA end joining and counters homologous recombination in BRCA1-null cells
BRCA1 deficiencies cause breast, ovarian and other cancers, and render tumours hypersensitive to PARP-inhibitors. To understand resistance mechanisms, we conducted whole-genome CRISPR-Cas9 synthetic-viability/resistance screens in BRCA1-deficient breast cancer cells treated with PARP-inhibitors. Thu...
ORGANISM(S): Homo sapiens (Human) 
2018-05-31 | PXD009830 | Pride
C20orf196 Shieldin Fam35a 
TranscriptomicsTranscription profiling of prostate tumors derived from the PSA-Cre;PtenLoxP/LoxP mouse prostate cancer model
1. Comparison of gene expression profiles of normal prostates, hyperplastic prostates (4-5 month old mice) and prostate tumors (>10 month old mice) isolated from PSA-Cre;Pten-loxP/loxP mice 2.Comparison of the gene expression profiles and molecular subtyping of prostate tumors isolated from targeted...
ORGANISM(S): Mus musculus 
2016-09-30 | E-MTAB-3970 | biostudies-arrayexpress
TranscriptomicsMaternal inhalation of surface-coated nano-sized titanium dioxide (UV-Titan): Effects in prenatally exposed offspring on hepatic DNA damage and gene expression
In the present study we investigate the effect of maternal pulmonary exposure to titanium dioxide (UV-Titan designed for use in the paint and lacquer industry) on prenatally exposed offspring. Time-mated mice (C57BL/6BomTac) were exposed by inhalation for 1 h/day to 42 mg UV-titan/m3 aerosolized pow...
ORGANISM(S): Mus musculus 
2012-03-19 | E-GEOD-29067 | biostudies-arrayexpress
TranscriptomicsPulmonary miRNA expression in C57BL/6 non-pregnant female mice intratracheally instilled with Printex 90 carbon black nanoparticles
miRNAs were measured in mice exposed to vehicle control (0.9% NaCl MilliQ water containing 10% v/v acellular BAL) or 0.162 mg Printex 90 in vehicle by intratracheal instillation and sacrificed 1, 3 and 28 days after exposure. C57BL/6 mice were exposed to 0.000 or 0.162 mg Printex 90 and sacrificed 1...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-36171 | biostudies-arrayexpress
TranscriptomicsPulmonary miRNA expression in C57BL/6 Bom Tac mice (dams) intratracheally instilled with Printex 90 carbon black nanoparticles
miRNAs were measured in pregant mice exposed to vehicle control (nanopure water) or a cumulative dose of 0.268 mg Printex 90 in vehicle by intratracheal instillation and sacrificed at weaning (26-27 days after exposure). Pregnant mice were exposed to vehicle control (nanopure water) or a cumulative ...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-36170 | biostudies-arrayexpress
TranscriptomicsImplication of Nos2 inactivation on genomic changes in Ptch1+/- medulloblastomas (array-CGH)
The Ptch1+/- strain constitues an established mouse model for the Shh-driven type of medulloblastoma. Combined Ptch1+/- Nos2-/- mice show a two-fold increased incidence for this tumor. Here, the impact of Nos2 inactivation on copy number alterations during medulloblastoma development was investigat...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-29199 | biostudies-arrayexpress
TranscriptomicsVariegated gene expression caused by cell-specific long-range DNA interactions
Mammalian genomes contain numerous DNA elements with potential transcription regulatory function but unknown target genes. We used transgenic, gain-of-function mice with an ectopic copy of the beta-globin locus control region (LCR) to better understand how regulatory elements dynamically search the ...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-24614 | biostudies-arrayexpress
TranscriptomicsLungs of mice exposed to subtoxic doses of nano-titanium dioxide particles by inhalation
Acute phase reactants serum amyloid A-1, 3 and micro RNA-135b, -449a, and -1 are induced in lungs of mice exposed to subtoxic doses of nano-titanium dioxide particles by inhalation In the present study we investigate pulmonary mRNA and miRNA profiles of mice exposed to subtoxic dose of nano-titanium...
ORGANISM(S): Mus musculus 
2010-12-13 | E-GEOD-19487 | biostudies-arrayexpress
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