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ProteomicsThe Role of FASN in bladder cancer
To dissect the mechanistic interplay between fatty acid metabolism and cigarette smoke–induced signaling in bladder cancer, we employed a proteomics analysis xenograft tumors derived from the UMUC3 with either stable FASN knockdown (KD) or control shRNA, with and without cigarette smoke. We performe...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-15 | PXD068785 | Pride
Proteomics Fasn Cigarette smoke Bladder cancer 
ProteomicsDetermination of protein expression changes due to treatment with chromatin remodeling inhibitor FHD-286 in patient-derived mutant NPM1 and FLT-ITD-expressing AML cells
We treated patient-derived mutant NPM1-and FLT3-ITD expressing AML cells with a chromatin remodeling inhibitor, FHD-286, at a dose of 100 nM, for 48 hours to determine FHD-286-mediated changes to the AML proteome.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047967 | Pride
Chromatin remodelers Mutant npm1 Aml Fhd-286 
ProteomicsDetermination of protein expression changes due to treatment with chromatin remodeling inhibitor FHD-286 in MLL1-rearranged AML cells
We treated MLL1-rearranged AML MOLM13 cells with a chromatin remodeling inhibitor, FHD-286, at a dose of 100 nM, for different time intervals (up to 48 hours) to measure the time-dependent changes to the AML proteome
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD047965 | Pride
Mll1-rearranged aml Chromatin remodelers Fhd-286 
ProteomicsAPEX proximity labeling of murine NDUFS4 interacting proteins in podocytes
In this project we used an unbiased approach to identify the proteins that interact with NDUFS4 in the mouse podocytes using the APEX2 proximity labeling system. An immortalized murine podocyte was permanently transduced with a doxycycline (DOX) inducible NDUFS4-APEX2 chimeric construct. The cells w...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-08 | PXD041378 | Pride
Apex proximity labeling of murine ndufs4 interacting proteins in podocytes 
ProteomicsLoss of function Dnmt3a mutation leads to aberrant neutrophil migration
To understand the impact of loss of function DNMT3A mutations in human patients, we performed proteomic analysis on serum samples of patients with Tatton-Brown-Rahman-Syndrome (TBRS). TBRS is an overgrowth syndrome caused by germline mutations in DNMT3A. Serum samples were obtained from 30 TBRS pati...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077276 | Pride
Dnmt3a  tatton-brown-rahman-syndrome (tbrs)  migration 
ProteomicsProtein identification of recombinant SLFN11 and SLFN14
The Schlafen (SLFN) family of nucleic acid binding proteins play an important role in gene regulation. In response to environmental stress, many SLFN members are activated for RNA cleavage and translational regulation. To characterize the RNA cleavage activity of this protein family, we produced rec...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD064237 | Pride
Schlafen Slfn11 Slfn14 
ProteomicsNF1-depleted ER+ breast cancers are differentially sensitive to CDK4/6 inhibitors
Neurofibromin/NF1-depletion (NF1low) is associated with endocrine therapy resistance in approximately 20% of ER+/HER2– early-stage breast cancer but specific treatments for NF1low tumors are not established. Proteogenomic analyses on ER+/HER2– breast cancer demonstrated that NF1low tumors exhibit e...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD052290 | Pride
Nf1 Neurofibromin 1 Cdk4 Raf Breast cancer Estrogen receptor 
ProteomicsEstrogen Receptor Mutant Coregulator
Biotinylated 4xERE-containing DNA immobilized on streptavidin beads used to pulldown proteins recruited by unliganded WT ER-alpha versus Y537S, D538G, or ESR1-YAP1 fusion proteins from HeLa S3 human cell nuclear extracts.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-02-08 | MSV000080536 | MassIVE
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