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TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
ProteomicsSplicing factor Ybx1 maintains persistent Jak2-mutated neoplasms via Mknk1-ERK-signaling
Janus kinases (Jak) mediate cytokine, hormone and growth factor responses in hematopoietic cells. Jak2 is one of the most frequently mutated genes in the aging hematopoietic system and in hematopoietic cancers. Mutations in Jak constitutively activate downstream signaling and are drivers of myelopro...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-20 | PXD006921 | Pride
Mpn Phosphoproteome Jak2 Hematological malignancy Splicing factor Erksignaling Ybx1 
TranscriptomicsMurine Ba/F3 Cells: Ba/F3 cells expressing wild type JAK2 (WT cells) vs. Ba/F3 cells expressing JAK2 V617F mutant (VF cells)
Transcriptional profiling of transformed Ba/F3 cells by myeloproliferative neoplasm-associated JAK2 V617F mutant comparing control Ba/F3 cells expressing wild type JAK2. Two-condition experiment, WT cells vs. VF cells. One replicate per array.
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-34239 | biostudies-arrayexpress
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
This dataset consists of 1 raw MS file and associated peak list and result file, acquired on an Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication. Publication title: "JAK2-CHK2 signaling safeguards the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-31 | MSV000087138 | MassIVE
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD056821 | Pride
Phosphorylation Chk2 Lc-ms/ms 
TranscriptomicsIntegrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a distinctive transcriptional profile. Notably, a transcriptional signature consistent with activated ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-54645 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibrosarcoma cells to study the relative contributions of Jak1 and Jak2 in IFNg signaling
General impact of Jak1 and Jak2 inhibition on IFNg-mediated target gene expression. U4C-Jak1AS and g2A-Jak2AS cells were stimulated with IFNg and treated with either 1NM-PP1 (to inhibit the activity only of the analog-sensitive mutant) or JI1 (to suppress both wild-type and analog-sensitive Jaks) fo...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-MEXP-2621 | biostudies-arrayexpress
GenomicsSuppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down Syndrome
Children with Down Syndrome (DS) are prone to development of high risk B-cell precursor ALL (DS-ALL) that differs genetically from most sporadic pediatric ALLs. Increased expression of CRLF2, the receptor to thymic stromal lymphopoietin (TSLP) characterizes about half of DS-ALLs and also a subgroup ...
EGAS00001002410 | EGA
ModelsBachmann2011_JAK2-STAT5_FeedbackControl
This model is from the article: Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Bachmann J, Raue A, Schilling M, Böhm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U. ...
2024-09-02 | BIOMD0000000347 | BioModels
GenomicsERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA [1]
ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA [1]
PRJNA1144894 | ENA
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