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MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsDistinct sub-cellular autophagy impairments occur independently of protein aggregation in aged induced neurons from patients with Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that is caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD in the lab has proven challenging as rodent models poorly reproduce the disease process and cellular models fail to include age-dependent processes crucial...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD024286 | Pride
Autophagy Direct neural reprogramming Huntington disease Crispr interference Proteogenomics Lentiviral vector 
TranscriptomicsIdentification of the miRNA targetome in hippocampal neurons using RIP-seq
We established a neuron-specific Argonaute2:GFP-RNA immunoprecipitation followed by high throughput sequencing (AGO2-RIP-seq) to analyse the regulatory role of miRNAs in mouse hippocampal neurons. Using this technique, we identified more than two thousand miRNA target genes in hippocampal neurons, r...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-65543 | biostudies-arrayexpress
ProteomicsMonoMac6 (MM6) cells proteomics LC-MS/MS
MicroRNAs (miRs) are small non-coding RNAs, which control the expression of target genes by either translational repression or RNA degradation, known as canonical miR function. MiR-328 has a non-canonical function and can activate gene expression by antagonizing the activity of heterogeneous ribonuc...
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD013106 | Pride
Inflammation Monomac6 (mm6) cells 
ProteomicsInhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells
We compared the effects of mPGES-1 inhibitor Compound III (CIII) with the cyclooxygenase (COX)-2 inhibitor NS-398 on protein and lipid profiles in interleukin (IL)-1β induced A549 lung cancer cells using mass spectrometry. Inhibition of mPGES-1 decreased PGE2 production and increased PGF2α and throm...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD013490 | Pride
Inflammation A549 Cancer Mpges-1 Lc-ms/ms 
TranscriptomicsComprehensive analysis of microRNA expression in the human developing brain reveals microRNA-10 as a caudalizing factor
MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-68189 | biostudies-arrayexpress
TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analysis of induced neurons from patients with Huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder that is caused by CAG expansions in the huntingtin (HTT) gene. Modelling HD in the lab has proven challenging as rodent models poorly reproduce the disease process and cellular models fail to include age-dependent processes crucial...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD055857 | Pride
Induced neurons Huntington disease 
TranscriptomicsComprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factorl
MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-71204 | biostudies-arrayexpress
UnknownImpact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease.
Not available
S-EPMC8204969 | biostudies-literature
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